摘要
目的:观察先天性心脏病房间隔缺损(ASD)患者置入封堵器后血浆凝血酶原片段1+2(F1+2)及血小板P选择素(CD62P)、血小板膜糖蛋白Ⅱb/Ⅲa受体(CD41a)的变化及其意义。方法:选择40例成功进行ASD封堵术的患者,用酶联免疫吸附测定法(ELISA)及流式细胞术(FCM)分别测定其术前、术后1～2d、术后1个月、术后3个月血浆F1+2水平及血小板CD62P、CD41a的表达。结果:①ASD患者术后1～2d较术前组的F1+2水平明显增高,术后1个月降低明显,术后3个月时恢复到接近术前的水平。②ASD患者术后1～2d、术后1个月、术后3个月的CD62P及CD41a表达均较术前明显下降。结论:ASD封堵术后凝血功能一过性增强,1个月后开始明显下降,3月后大致恢复术前水平;血小板活性在术后降低。
Objective：To investigate the changes of the levels of prothrombin fragment 1 ＋ 2 （F] ＋ 2）, P-selectin （CD62P） and platelet glycoprotein Ⅱb/Ⅲ a receptor （CD41a） among patients following transcatheter ASD closure. Methods： Forty consecutive patients who underwent successful transcatheter closure of an ASD defect with the domestic-made septal occluder were prospectively studied. Measurements of the F1 ＋ 2 levels and the percent- age of activated platelets （evaluated by CD62P and CD41a） expression detected by flow cytometry were taken at baseline just before the procedure, at 1 day, 30 days and 90 days following device implantation. Resuits：（1）F1 ＋ 2 levels increased from baseline to a maximal value at 1st day, gradually returning to the baseline levels at 90th day. （2）CD62P and CD41a decreased at 1, 30 and 90 days. Conclusion：Transcatheter closure of ASDs with the domes- tic-made septal occluder was associated with significant increase of coagulation activation and a significant decrease of the platelet activation.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2009年第10期769-772,共4页
Journal of Clinical Cardiology
基金
广西科技攻关项目(桂科攻No:0472002-30)
