摘要
综合分析了国际国内近年来有关核骨架研究的新进展，从几个方面的研究事实，包括核骨架对染色质ＤＮＡ的有序组织、核骨架参与ＤＮＡ复制和基因的表达与调控以及核骨架的起源进化等，阐明核骨架是细胞核内染色质结构的有序组织者和功能活动的参与者；核内纷繁复杂的生命活动能有条不紊地进行，核骨架在其中扮演了重要角色。
Evidence for that nuclear matrix is the structural and functional organizer of eukaryotic chromatins were reviewed here. (1)Chromosomal DNA is looped into domains by attachment of the chromatin fibre to the nuclear matrix. The studies of MAR (matrix-associated region) and of the nuclear matrix proteins that bind specifically to MAR are uncovering the essence of the problem. (2)Nuclear matrix is involved in DNA replication. This has been demonstrated by evidence that replication forks,replication origins and enzymes or factors involved in replication were all matrix-associated. (3)Evidence also showed that nuclear matrix was involved in RNA transcription,processing and transport. (4)Our data showed that nuclear matrix originated very early,it was argued that its origin must be the necessity of providing new structural and functional organizer for eukaryotic chromatins when eukaryotic chromatins evolved from prokaryotic chromatins in the process of origin of the eukaryotic cell.
基金
国家自然科学基金
关键词
核骨架
染色质
DNA复制
基因表达
调控
Nuclear matrix,Chromatin,DNA replication,Gene expression and regulation,Origin and evolution
