摘要
心肌营养素１（ｃａｒｄｉｏｔｒｏｐｈｉｎ１，ＣＴ１）是一个新发现的白介素６家族细胞因子，小鼠ＣＴ１的ｍＲＮＡ长约１４ｋｂ，编码蛋白由２０３个氨基酸组成，以ｇｐ１３０和ＬＩＦＲ为受体．ＣＴ１对心肌细胞既有肥大诱导作用，又有保护作用；能改变交感神经元的递质表型，促进多巴胺神经元、睫状神经元和运动神经元的存活；还能抑制骨髓白血病细胞Ｍ１的生长；诱导肝细胞急性相反应；小鼠腹腔注射给药可增加血小板。
Cardiotrophin-1 is a novel member of the interleukin-6 cytokine family. Mouse CT-1 mRNA is about 1 4 kb in length, and the encoded protein contains a 203aa open reading frame. It utilizes gp130 and LIFR as the signal transducing receptor components. As a multifunctional cytokine, it induces cardiac myocyte hypertrophy and promote cardiac myocyte survival. It can induce a phenotypic switch in rat sympathetic neurons and promote the survival of dopaminergic neurons, ciliary neurons and motoneurons. It can also inhibit the growth of the mouse myeloid leukemia cell M1, and induce liver acute phase response. The chronic administration of CT-1 to mouse increases platelet counts, red blood cell counts and haemoglobin concentration.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1998年第4期295-298,共4页
Progress In Biochemistry and Biophysics
