摘要
目的研究失眠症患者连续服用佐匹克隆或右佐匹克隆(镇静催眠药)于治疗前后多导睡眠图(PSG)的变化。方法27例失眠症患者随机入组后,给予佐匹克隆或右佐匹克隆治疗2周,分析组内、组间PSG和睡眠障碍量表(SDRS)于治疗前后的变化。结果佐匹克隆组,PSG各指标治疗后均有改变,但变化不显著;右佐匹克隆组,治疗后PSG示,总睡眠时间延长、睡眠效率升高、入睡后觉醒时间减少;治疗前后PSG各指标差值,组间比较差异无统计学意义。治疗后2组SDRS评分均明显降低;但治疗前后差值,组间比较差异无统计学意义。2组药物不良反应发生率分别为55.6%和60.0%。结论佐匹克隆和右佐匹克隆对失眠症患者PSG各指标有相似的影响。
Objective To study the change of polysomnogram （PSG） in the insomniac patients who took one of the hypnotics ,zopiclone or eszopiclone. Methods Twenty-seven subjects ,who met the 3th edition of the Chinese Classification and Diagnostic Criteria of Mental Disorders 3 （CCMD-3） criteria for insomnia,were divided into two groups randomly. Each patient was given 7.5 mg zopiclone or 3 mg eszopiclone everynight for two weeks. Overnight PSG were recorded and sleep dysfunction rating scale （SDRS） were evaluated before and after the administration of drug. Results Zopiclone influenced all parameters of all-night PSG but the influence wasn＇t significant. Eszopiclone had significant effects on some parameters of all-night PSG, including longer total sleep time, higher sleep efficiency, decreased wake time after sleep onset. Effect of the two hypnotics on all-night PSG were similar. SDRS of two groups both decreased greatly but no difference between them. Incidence of adverse reactions in two groups is 55.6% and 60. 0%, respectively. Conclusion Both zopiclone and eszopiclone influence on all parameters of overnight PSG and the effect of the two hypnotics were similar.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2009年第5期402-404,共3页
The Chinese Journal of Clinical Pharmacology
