摘要
目的:观察经犬肾动脉灌注平阳霉素(PYM)和平阳霉素碘油乳剂(PLE)产生的肾血管损伤,以验证PLE对血管的栓塞作用。方法:29只雄性家犬分3组:假手术组、PYM组和PLE组。PYM组在药物灌注后1、7和14天取材,PLE组在1、3、7、14、28和56天取材,观察各组肾血管的病理改变。结果:PYM组药物灌注后1天表现为局灶性血管内膜轻度肿胀,以肾小球毛细血管袢为主;7天内膜肿胀减轻;14天内膜形态基本恢复正常。PLE组早期(1～7天),肾脏毛细血管袢和动脉中膜(以小叶间动脉和入球小动脉为主)纤维素样坏死,伴血栓形成和血管周围炎细胞浸润;后期(14～56天)以血管壁平滑肌增生和纤维化,管腔狭窄和闭塞为主;两组均对静脉损伤轻微。结论:PLE较单纯PYM对肾血管的损伤作用早且持久,可能作为一种新的末梢栓塞剂用于临床血管栓塞术。
Objective：To investigate the pathologic changes of kidney vessels after intra-arterial infusion of pingyangmycin（PYM）or pingyangmyein-lipiodol emulsion （PLE）in dogs. Methods： Thirty-one canis familiaris were divided into control group, PYM group, and PLE group. Right renal arteries were selectively infused with PYM solution （PYM group） or PLE （PLE group） by Seldinger＇s technique and selective catherization. The pathologic changes of kidney blood vessels were observed at the following l, 3,7,14,28,56 days of PLE group and 1,7,14 days of PYM group. Results：The lesions of renal vessels in PYM group were slight,characteristics of which was focal mild intima swelling of glomerular capillaries at 1st and 7th day and nearly recovery at 14th day. After PLE treatment within 7 days,fibrinoid necrosis occurred in glomerular capillary loops and tunica media of arterioles,mainly interlobular arteries and afferent glomerular arteriole,companied by thrombosis and inflammational cells infiltration around blood vessel. Since 14th day,proliferation of vascular smooth muscle cells and fibrosis of vessel wall have increasingly become apparent,ultimately resulting in stenosis and occlusion of damaged arteries. Conclusion：The lesion of renal vessels were earlier and more lasting by PLE renal arterial injection compared with PYM. PLE may be used as one new embolism agent in embolization.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第11期1538-1541,共4页
Journal of Nanjing Medical University(Natural Sciences)
