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硫化氢与系统功能调节

Hydrogen sulfide and the regulation of system function
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摘要 硫化氢（H2S）在哺乳动物组织中大量产生，并且作为调节介质发挥多种理学效应。研究证明，H2S是继NO和CO之后发现的一种新的气体信号分子。H2S参与血管张力、心肌收缩力、神经递质和胰岛素分泌的调节，很多系统的功能调节与H2S有关。动脉高压、阿尔茨海默病、胃黏膜损伤和肝硬化的动物模型中均有H2S的缺乏，而外源性H2S可以改善与缺血／再灌注损伤相关的心功能不全，减少抗炎药物引起的胃黏膜损伤。本文对H2S在体内不同系统中的产生、功能调节及可能的作用机制进行综述，力求将H2S的系统功能调节作用展示出来。 Hydrogen sulfide（H2S） is produced in mammalian tissues and have many physiological effects. Recent studies suggest that H2S is the third gaseous mediator in mammals besides NO（nitric oxide） and CO （carbon monoxide）. H2S is involved in the regulation of angiotasis, myocardial contractility, neurotransmitter and insulin secretion. H2S is associated with system function. H2S deficiency was observed in various animal models of arterial and pulmonary hypertention, Alzheimer＇s disease, gastric mucosal injury and liver cirrhosis. Endogenous H2S ameliorates myocardial dysfunction associated with the ischemia/reperfusion injury and reduces the damage of gastric mucosa induced by anti- inflam- matory drugs. We sum up the production, regulation function and possible mechanism of H2S in different systems.
作者 史迪 俞佳 于学忠
机构地区 中国医学科学院中国协和医学院北京协和医院急诊科
出处 《中国急救医学》 CAS CSCD 北大核心 2009年第11期966-969,共4页 Chinese Journal of Critical Care Medicine
关键词 硫化氢 神经系统 心血管系统 内分泌系统 消化系统 Hydrogen sulfide （H2S） Nervous system Cardiovascular system Endocrine system Digestive system
分类号 R364.5 [医药卫生—病理学]
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参考文献28

  • 1Warenycia MW, Goodwin LR, Benishin CG, et al. Acute hydrogen sulfide poisoning. Demonstration of selective uptake of sulfide by the brainstem by measurement of brain sulfide levels[J]. Biochem Pharmacol, 1989,15,38 (6) :973 - 981.
  • 2Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator 1[J]. J Neurosci, 1996, 16(3) :1066 - 1071.
  • 3Kimura H. Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor[ J ]. Biochem Biophys Res Commun, 2000,267 (1) : 129 - 133.
  • 4Nagai Y, Tsugane M, Oka J, et al. Hydrogen sulfide induces calcium waves in astrocytes[ J]. FASEB J, 2004, 18(3) :557 -559.
  • 5Pataechini R, Santicioli P, Giuliani S, et al. Hydrogen sulfide ( H2S) stimulates capsaicin - sensitive primary afferent neurons in the rat urinary bladder [ J ]. Br J Pharmacol,2004,142 ( 1 ) :31 - 34.
  • 6Belardinelli MC, Chabli A, Chadefaux - Vekemans B, et al. Urinary sulfur compounds in Down syndrome[ J ]. Clin Chem, 2001,47 ( 8 ) : 1500 - 1501.
  • 7Kamoun P. Mental retardation in Down syndrome: a hydrogen sulfide hypothesis[ J ]. Med Hypotheses ,2001,57 ( 3 ) :389 - 392.
  • 8Qu K, Chen CP, Halliwell B, et al. Hydrogen sulfide is a mediator of cerebral ischemlc damage[ J]. Stroke,2006,37 (3) :889 - 893.
  • 9Wong PT, Qu K, Chimon GN, et al. High plasma cysteine level may indicate poor clinical outcome in patients with acute stroke: possible involvement of hydrogen sulfide[ J]. J Neuropathol Exp Neuro,2006, 65(2) :109 - 115.
  • 10Kimura Y, Dargusch R, Schubert D, et al. Hydrogen sulfide protects HT22 neuronal cells from oxidative stress[ J]. Antioxid Redox Signal,2006,8(3 -4) :661 -670.

二级参考文献23

  • 1[1]Ignarro LJ. Biological action and properties of endothelium derived nitric oxide formed and released from artery and vein. Circ Res, 1989;65(1):1～21
  • 2[2]Wang R. Resurgence of carbon monoxide:An endogenous gaseous vasorelaxing factor. Can J Physiol Pharmacol, 1998;76(1):1～15
  • 3[3]Alexander MY, Brosnan MJ, Hamiltan CA. Gene transfer of endothelial nitric oxide synthase improves nitric oxide-dependant endothelial function in a hypertensive rat model. Cardiovascular Research, 1999;43(3):798～807
  • 4[4]Sabaawy HE, Zhang F, Nguyen X. Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats. Hypertension, 2001;38(2):210～6
  • 5[5]Wang R. Two's company, three's a crowd:Can H2S be the third endogenous gaseous transmitter? FASEB J, 2002;16(13):1792～8
  • 6[6]Zhao WM, Zhang J, Lu YJ, Wang R. The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener. EMBO J, 2001;20(21):6008～16
  • 7[7]Furchgott RF, Zawadrki JV. The obligatory role of endothelium cells in the relaxation of arterial smooth muscle by acecylcholine. Nature (Land), 1980;288(5789):373～6
  • 8[8]Hosok R, Matsuki N, Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun,1997;237(3):527～31
  • 9[9]Declan L. Impairment and restoration of nitric oxide-dependent vasodilation in cardiovascular disease. Inter J cardio, 1997;62(Suppl 2):S101～9
  • 10Hosoki R,Matsuki N,Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun,1997,237:527-531.

共引文献56

中国急救医学
2009年 第11期

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