摘要
目的：探讨一氧化氮（ＮＯ）与胰岛素依赖型糖尿病（ＩＤＤＭ）之间的关系。方法：对３２例ＩＤＤＭ患儿和２８例正常健康儿童血清，采用比色法检测ＮＯ和以邻苯三酚自氧化法检测超氧化物歧化酶（ＳＯＤ）水平。结果：ＩＤＤＭ组患儿血清ＮＯ水平明显高于正常组（Ｐ＜００１），而ＳＯＤ水平明显低于正常组（Ｐ＜００１）；ＩＤＤＭ中伴血管并发症者与无血管并发症者比较，前者血清ＮＯ的增高和ＳＯＤ的下降更为显著（均Ｐ＜００５）；患儿血清ＮＯ与空腹血糖呈明显正相关（ｒ＝０７３５，Ｐ＜００１），与ＳＯＤ呈负相关（ｒ＝－０４４９，Ｐ＜００５），而与病程无明显相关性；血清ＳＯＤ与空腹血糖、病程均无相关性。结论：ＮＯ参与了ＩＤＤＭ及其并发症的发生与发展。
Objective:To study the relationship between nitric oxide(NO)and insulin-dependent diabetes mellitus(IDDM) Methods:Colorimetry and autoxidation of pyrogallol were used to determine NO and SOD levels in the serum of 32 patients with IDDM and 28 normal controls Results:The serum NO level was markedly higher(P<0 001),while SOD level was significantly lower than that of normal controls(P<0 001) Compared with patients without angiopathy,the increase of NO and decrease of SOD in patients with angiopathy were more obvious(P<0 05,respectively) In patients with IDDM,serum NO had significantly positive correlation with fasting blood glucose concentrations(r=0 735,P<0 001),and negative correlation with serum SOD(r=-0 449,P<0 05),but had no correlation with the duration Serum SOD had no correlation with fasting blood glucose or the duration Conclusion:NO might contribute to the development and progress of IDDM \ \
出处
《中国实用儿科杂志》
CSCD
北大核心
1998年第6期341-342,共2页
Chinese Journal of Practical Pediatrics
