摘要
目的:研究4种不同类型的抗高血压药物对血压变异性(blood pressure variability,BPV)的影响。方法:99例轻、中度原发性高血压患者,分别服用多沙唑嗪1mg/d(30例)、塞利洛尔100mg/d(18例)、咪达普利5mg/d(31例)和左旋氨氯地平2.5mg/d(20例),比较治疗前和治疗8周后动态血压和BPV的变化。结果:①多沙唑嗪、咪达普利和左旋氨氯地平组白昼的收缩压和舒张压分别降低9.67/6.64mmHg(1mmHg=0.133kPa)、5.06/2.39mmHg和9.65/5.35mmHg,而左旋氨氯地平组还降低夜间的收缩压和舒张压12.60/8.45mmHg;②多沙唑嗪组和左旋氨氯地平组能降低BPV,多沙唑嗪组24h收缩压、舒张压和白昼的收缩压变异分别减少19.0%、13.8%和12.5%(P<0.05或P<0.01),左旋氨氯地平组夜间收缩压、舒张压变异分别减少27.4%和18.1%(P<0.01和P<0.05)。结论:①多沙唑嗪、咪达普利和左旋氨氯地平组白昼的降压幅度较为明显,而左旋氨氯地平组还能降低夜间的血压;②多沙唑嗪组和左旋氨氯地平组能降低BPV。
Objective To observe the impacts of 4 different anti-hypertensive agents on blood pressure variability （BPV） in patients with essential hypertension （EH）. Methods Ninety-nine patients with EH were divided into 4 groups, and were treated with doxazosin 1 mg/d （n=30）, celiprolol 100 mg/d （n=18） or imidapril 5 mg/d （n=31） and L-amlodipine 2.5 mg/d （n=20）, respectively. The changes of 24-hour average blood pressure and BPV were compared prior to and after 8 weeks of treatment. Results The reductive values of systolic/diastolic blood pressure at daytime in doxazosin group, imidapril group and L-amlodipine groups were 9.67/6.64, 5.06 /2.39 and 9.65/5.35 mm Hg, respectively. Furthermore, the reductive values of systolic and diastolic blood pressure at nighttime were 12.60 and 8.45 mm Hg in L-amlodipine group. The reduction of BPV was observed in doxazosin group and L-amlodipine group. In doxazosin group, the reductive values of systolic blood pressure variability, diastolic blood pressure variability at 24 h, and variabilities of systolic blood pressure at daytime were 19.0%, 13.8% and 12.5%, respectively（P〈0.05 or P〈0.01）. In L-amlodipine group, the reductive values of systolic and BPV at night time were 27.4% and 18.1% respectively （P〈0.01, P〈0.05）. Conclusions Doxazosin, imidapril and L-amlodipine demonstrate significant daytime blood pressure control. Furthermore, L-amlodipine could reduce the blood pressure at nighttime. Both doxazosin and L-amlodipine demonstrate their efficacy on BPV reduction.
出处
《内科理论与实践》
2007年第3期179-182,共4页
Journal of Internal Medicine Concepts & Practice
基金
上海市卫生局发展基金资助(项目编号:01466)
关键词
原发性高血压
血压变异性
抗高血压药物
动态血压监测
Essential hypertension
Blood pressure variability
Anti-hypertensive drugs
Ambulatory blood pressure monitoring
