摘要
目的：探讨血脂康对实验性家兔动脉粥样硬化（ＡＳ）的形成及其脂质过氧化损伤的影响。方法：将纯种新西兰白兔采用随机分层分组法分为３组，即对照组、高脂组和治疗组。以高胆固醇饮食建立家兔动脉粥样硬化模型观察各组家兔血脂、血浆过氧化脂质、超氧化物歧化酶及主动脉、冠状动脉的病理改变。结果：血脂康能明显降低高胆固醇饮食家兔血清胆固醇、甘油三酯、低密度脂蛋白胆固醇含量（Ｐ＜０．０５），轻度增加血清高密度脂蛋白胆固醇含量（Ｐ＞０．０５），明显地抑制血浆过氧化脂质的形成（Ｐ＜０．０５）及超氧化物歧化酶含量的降低（Ｐ＜０．０５）；抑制肝脏、肾脏过氧化脂质的形成及超氧化物歧化酶含量的降低（Ｐ＜０．０５）。治疗组主动脉硬化斑块面积与动脉总面积比值明显降低，泡沫细胞层数明显减少，主动脉及冠状动脉病变明显减轻。结论：血脂康具有明显的调整血脂。
Objective:To study the antiatherogenetic and anti lipid hyperoxidatic effects of Xuezhikang in cholesterol fed rabbits. Methods:The New Zealand white rabbits were randomized into three groups:control group,high lipid group and therapy group.The changes of serum total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol( HDL C ),low density lipoprotein cholesterol(LDL C),lipid peroxide(LPO),superoxide dismutase(SOD)concentrations and the histopathological changes of aorta and coronary arteries were detected. Results:Xuezhikang could remarkably decrease the level of TC,TG,LDL C in serum of rabbits fed a high cholesterol diet( p <0 05),mildly increase the level of HDL C in serum( p >0 05).Xuezhikang could remarkably inhibit the formation of LPO in plasma( p <0 05),liver and kidney( p <0 05),and the decrease of SOD in the therapy group( p <0 05),the ratio of the area of atherogetic decreased,the layers of foamcells were remarkably decreased,the lesion of the aorta and coronary artery was remarkably depressed. Conclusion:Xuezhikang was remarkably effective to modulate the lipid metabolism and to inhibit the injury formation of and of lipid hyperoxidation.
出处
《中国循环杂志》
CSCD
北大核心
1998年第5期305-307,共3页
Chinese Circulation Journal
