摘要
采用３Ｈ－ＴｄＲ释放法分别检测了单纯ＮＫ细胞活性及红细胞作用下ＮＫ细胞的活性，结果显示肺癌患者外周血ＮＫ细胞活性（２３．７８％±６．３４％）较正常对照组（４１．３７％±７．４３％）明显降低（Ｐ＜０．００５），但在正常人红细胞作用下，其ＮＫ细胞毒活性为３０．３０％±６．５６％，经配对设计ｔ检验有显著性差异（Ｐ＜０．００１）；在肺癌患者红细胞作用下，机体ＮＫ细胞活性无明显变化，经检验不存在显著性差异（Ｐ＞０．０５）。表明正常人红细胞对自身及肺癌患者的ＮＫ细胞活性均有显著的促进作用，在肿瘤免疫学及临床肿瘤的治疗方面将有积极的意义。
In order to investigate the activity of normal erythrocytes on natural killer cells in peripheral blood of patients with lung cnacer, we used a 3H Thymidine release assay to measure natural killer mediated cytotoxicity before and after being precoated with cystosol of erythrocytes. The study demonstrated that activity of natural killer cells in patients (23.78±6.34%) ( P <0.005) was significantly lower than that of normal controls (41.37± 7.43%) .However, it could be greatly enhanced (30.30±8.58%) by normal erythrocytes ( P <0.001). Erythrocytes of patients with lung cancer had no effect on natural natural killer cytolysis ( P >0.05). These results indicated that normal erythrocytes could augment activity of natural killer cells both of autochthon and of patients with lung cancer which probably play and important role in tumor immunology.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第10期719-721,共3页
Chinese Journal of Clinical Oncology
关键词
肺肿瘤
外周血
NK细胞
红细胞
Erythrocytes Lung cancer Natural killer cells
