摘要
应用免疫组化方法，对１０１例有８年随访结果的乳腺癌病例，进行了ｎｍ２３基因蛋白表达的检测。结果显示，ｎｍ２３基因蛋白表达与血行转移、淋巴结转移的发生呈负相关，与其它临床指标无关。生存率分析表明：ｎｍ２３基因高表达组患者的生存率明显高于低表达组（Ｐ＜０．０５）；腋淋巴结阴性组中，ｎｍ２３基因高、低表达的患者生存率差别显著，提示若将腋淋巴结阴性组中具有潜在转移危险性的ｎｍ２３低表达患者筛选出来，加强治疗，将会有助于提高生存率。应用Ｃｏｘ比例风险模型进行的多因素分析显示，ｎｍ２３基因表达与腋淋巴结转移、肿瘤大小均为乳腺癌的预后因素，其中ｎｍ２３基因高表达患者死亡的相对危险度较低表达患者低５４％。本研究结果提示，ｎｍ２３基因表达可以作为一项独立的预后指标，用以指导乳腺癌的临床治疗。
Expression of nm23 gene protein in 101 breast cancer patients was detected by means of immunohistochemistry. Expression of nm23 gene was inversely associated with lymph node involvement and distant metastasis ( P <0.05). Overall survival was better in nm23 positive patients than that in the negatives. In multiple factor analysis using a Cox's proportional hazard regression model, nm23 was correlated with the patient's survival (B=0.4288). This study showed that nm23 gene may be taken as an independent marker in assessing prognosis in addition to its role in breast cancer metastasis.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第10期714-718,共5页
Chinese Journal of Clinical Oncology
基金
国家"九五"攻关项目基金
关键词
NM23基因
乳腺癌
预后
肿瘤转移
nm23 gene Breast carcinoma Distal metastasis Prognosis Immunohistochemistry
