摘要
目的 :探讨nm2 3基因表达与宫颈癌转移及预后的关系。方法 :采用免疫组化方法 ,检测经病理证实的 30例正常宫颈上皮组织 (对照组 )及 5 5例宫颈癌组织 (实验组 )中nm2 3的表达水平。结果 :(1)在正常宫颈组织中 ,2 9例呈nm2 3高表达 (96 .7% ) ,仅 1例呈nm2 3低表达 (3.3% ) ,在宫颈癌组织中 19例呈nm2 3高表达 (34.4 % ) ,36例为nm2 3低表达 (6 5 .6 % ) ,差异有显著性 (P <0 .0 1)。 (2 )nm2 3在宫颈癌临床分期晚、细胞分化程度差、有转移、复发及预后差的患者中表达显著降低 (P <0 .0 1)。结论 :nm2 3的表达可作为反映宫颈癌恶性潜能的指标之一。
Objective:To investigate the relationship between nm23 expression and metastasis and prognosis of cervical carcinoma.Methods:nm23 expression was detected by immunohistochemical method in 55 cervical cancers and 30 normal cervical specimens.Results:nm23 expression was obviously lower in cervical cancer than that in normal cervix( P< 0.01).The patients with advanced stage,poor differentiation,metastasis,recurrence and poor prognosis of cervical cancer had a significant downexpression of nm23( P< 0.05～0.01).Conclusion:nm23 down regulation could be an indicator of metastatic potential and poor prognosis.
出处
《广东医学院学报》
2003年第4期321-323,共3页
Journal of Guangdong Medical College
关键词
抑癌基因
基因表达
预后
宫颈肿瘤
suppressor gene
tumor
gene expression
prognosis
cervical neoplasm
