摘要
目的研究不同免疫状态下，白念珠菌在小鼠肠道增殖及播散的情况。方法给经口饲白念珠菌液的小鼠口服庆大霉素、甲硝唑，腹腔注射环磷酰胺、氨甲蝶呤等处理，持续３～４周，此间每隔１周处死数只小鼠，检查其盲肠及内脏器官的白念珠菌菌落数。结果某些抗生素和免疫抑制剂处理能增加小鼠肠道内白念珠菌定居数量（Ｐ＜０．０１）；两类药物联合应用时，作用更为显著，并可使白念珠菌向内脏播散，甚或致死。
Objective\ To study how Candida albicans colonied and disseminated from gastrointestinal tract of mice which were in different immune states.\ Methods\ Mice fed with Candida albicans,were given gentamicin or metronidazole in their drinking water,of given cyclophosphamide or methotrexate by intraperitoneal injection over 3～4 weeks period.\ At weekly intervals,Candida albicans colonies in their gastrointestinal tract and viceral organs were counted.\ Results\ some antibiotics and immunosuppressants may facilitate colonization of Candida albicans in gastrointestinal tract of those mice(P<0 01) respecially,in the animals treated with these two kinds medicine had higher cecal candida counts and were more likely to disseminate than others.\ Conclusion\ The candida counts in the host intestinal tract and host′s state of immune are important factors on disseminated candidiasis.
出处
《福建医科大学学报》
1998年第3期233-235,共3页
Journal of Fujian Medical University
关键词
白念珠菌病
抗生素
免疫抑制
机体免疫状态
candidiasis
\ antibiotics
\ immunosuppression
\ animals,laboratory
