摘要
目的 :探讨肇庆地区健康人群人类细小病毒 B19感染状况。方法 :采用巢式聚合酶链反应(Nested- PCR)技术包括对 4 11名新生儿、 186名婴幼儿童、 374名成人、 689名孕妇的健康人 1662名的脐血或指端、静脉血检测 B19DNA。结果 :1662名 B19阳性检出率为 8.72 %,无性别差异。其中正常新生儿 B19阳性检出率 10 .71%接近孕妇 10 .2 7%,均高于正常成人的 5 .0 8%(P<0 .0 1)。婴幼儿童B19阳性检出率与成人无显著差异。结论 :健康人 B19感染率为 5 .0 8%至 10 .71%,新生儿与孕妇机体分别处于初生与特殊生理状态 ,免疫力与抗感染能力低于正常婴幼儿童与正常人 ,B19感染率高 ,值得重视。应防止多胎妊娠 ,坚持计划生育与优生。
Objective:To study the prevalence of haman parvovirus B 19 infection in healthy resident population in Zhaoqing.Methods:Human parvovirus B 19 DNA from umbilical or finger-tip or venous blood was detected with nested-PCR in 1 662 cases of healthy subjects,icluding 411 newborns,186 infants,374 normal adults and 689 pregnant women.Results:The positive detective rates were 8.72% in all subjects,10.71% in newborns,10.27% in pregnant women and 5.08% in normal adults,respectively.The newborns and pregnant women had higher positive detective rate than adults(P<0.01),but no significant difference existed between infants and adults,and no sex difference was found.Conclusions:The positive infection rate of parvovirus B 19 in healthy population ranges from 5.08% to 10.71%,with higher rate in newborns and pregnant women. Owing to lower immunity and resistance to infeeton as physiological cause. The study suggests that multiple pregnancy shoud be prevented,and the policy of family planning and aristogenesis should be adopted.
出处
《新医学》
1998年第11期581-582,共2页
Journal of New Medicine
