摘要
目的:为翼状胬肉发病机制和临床治疗研究提供参考。方法:免疫组织化学方法检测20例翼状胬肉病理组织中基质金属蛋白酶-3(MMP-3)的表达情况。结果:翼状胬肉病理标本MMP-3阳性(+)表达13例(65%),强阳性(++)3例(15%),总阳性表达率(阳性+强阳性)为80%,对照组标本均呈阴性表达,两组经统计学分析有显著性差异(P<0.01)。结论:MMP-3在翼状胬肉病理标本中有较高水平的表达,MMP-3的高水平表达可能是翼状胬肉发病和术后复发的一个重要因素;临床在手术治疗翼状胬肉的同时,若能干预或抑制MMP-3的活性,有可能大幅减少翼状胬肉病例术后的复发率。
Objective To study the expression of MMP-3 in surgical specimens of pterygia.Methods Immunohistochemistry was used to detect the expression of matrix metalloproteinase-3（MMP-3） in 20 pathological specimens of pterygia.Results The expression of MMP-3 was（＋） 13/20（65.0%） and（＋＋） 3/20（15.0%） and the total positive rate was 80%.While in the control specimens of limbus region from cataract patients,the expressions of MMP-3 were all negative（0/15）（positive rate 0,vs pterygia,P〈0.01）.Conclusion A higher expression of MMP-3 could be seen in the pathological tissues of pterygia,which may play important role for postoperative recurrence.The recurrence rate of pterygia might be decreased if the activity of MMP-3 could be inhibited as a part of treatment.
出处
《放射免疫学杂志》
CAS
2009年第5期540-541,共2页
Journal of Radioimmanology
