摘要
目的:探讨了脑梗死患者治疗前后血浆Hcy和血清GM-CSF和hs-CRP水平的变化及临床意义。方法:应用化学发光法、放射免疫分析和免疫比浊法对32例脑梗死患者进行了治疗前后血浆Hcy和血清GM-CSF和hs-CRP检测,并与35名正常健康人作比较。结果:治疗前脑梗死患者血浆Hcy和血清GM-CSF和hs-CRP水平非常显著地高于正常人组(P<0.01)。经3个月治疗后血浆Hcy和血清GM-CSF和hs-CRP水平与正常人组比较无显著性差异(P>0.05)。患者组治疗前后血浆Hcy有显著差异(P<0.01)。结论:Hcy可能造成血管内皮损伤及功能的改变,对脑梗死的发生发展有促进作用,血清GM-CSF和hs-CRP水平的变化与患者的病情和预后密切相关,有重要的临床价值。
Objective To study the clinical significance of changes of plasma Hey and serum GM-CSF,hs-CRP levels in patients with cerebral infarction.Methods Plasma Hcy levels（with CLIA）,serum GM-CSF levels（with RIA） and serum hs-CRP levels（with Immune-turbidimetry method） were determined in 32 patients with cerebral imfarction both before and after treatment as well as in 35 controls.Results Before treatment,the plasma Hcy and serum GM-CSF,hs-CRP levels in the patients were significantly higher than those in controls（P〈0.01）.After 3 months＇ treatment these levels were not significantly different from those in controls（P〉0.05）.The levels in patients before treatment were significantly higher than those after treatment（P〈0.01）.Conclusion Homocysteine（Hcy） may cause injury and functional damage to endothelial cells,which contributes to the development and progression of cerebral ingarction.Changes of serum GM-CSF and hs-CRP levels would be of prognostic value in patients with cerebral infarction.
出处
《放射免疫学杂志》
CAS
2009年第5期470-472,共3页
Journal of Radioimmanology
关键词
脑梗死
同型半胱氨酸
粒细胞巨噬细胞集落刺激因子
超敏C反应蛋白
cerebral infarction
homocysteine（Hcy）
granalocyte-macrophage colony stimulating factor（GM-CSF）
high sensitive C relative protein（hs-CRP）
