摘要
目的:探讨妊娠糖尿病患者血浆hs-CRP、sICAM-1和TNF-α水平的变化与患者发病的关系。方法:30例正常孕妇(对照组)及30例妊娠糖尿病(GDM)患者的血清sICAM-1和TNF-α含量均采用放射免疫分析;hs-CRP水平采用免疫比浊法。结果:30例GDM患者血清hs-CRP水平与对照组比较增高非常明显(P<0.01);sICAM-1水平GDM患者与对照组比较增高也非常明显(P<0.01);TNF-α水平数据统计显示,GDM患者与对照组比较增高同样非常明显(P<0.01)。提示GDM患者三项血清指标均极显著高于对照组。相关分析显示,hs-CRP与sICAM-1和TNF-α均呈显著正相关(r=0.509,P<0.01;r=0.63,P<0.01)。结论:妊娠糖尿病患者血清三项指标的测定对于了解和认识其发病机理及预估病情有帮助。
Objective To study the relationship between changes of serum sensitive C-reactive protein（hs-CRP）,tumor necrosis factor-alpha（TNF-α） and soluble intercellular adhesion molecule-1（sICAM-1） levels and development of the disease in patients with gestational diabetes mellitus（GDM）.Methods Serum levels of TNF-α and sICAM-1（with RIA） and hs-CRP（with immunoturbidimetry） were measured in 30 patients with GDM and 30 normal pregnant women as controls.Results The serum hs-CRP,sICAM-1 and TNF-α contents in the patients with GDM were all significantly higher than those in normal pregnant women（all P〈0.01）.The serum hs-CRP levels were mutually positivety correlated with TNF-α and sICAM-1 levels（r=0.6097,0.7213,all P〈0.01）.Conclusion Determination of changes of serum hs-CRP,TNF-α and sICAM-1 levels in patients with gestational diabetes mellitus would be helpful for outcome prediction.
出处
《放射免疫学杂志》
CAS
2009年第5期442-444,共3页
Journal of Radioimmanology
关键词
妊娠糖尿病
高敏C-反应蛋白
可溶性细胞间黏附分子-1
肿瘤坏死因子-α
gestational diabetes mellitus（GDM）
sensitive C-reactive protein（hs-CRP）
tumor necrosis factor-alpha（TNF-α）
soluble intereellular adhesion molecule-1（sICAM-1）
