摘要
目的探讨转录因子Twist在涎腺腺样囊性癌中的表达水平及其与各临床病理因素的关系。方法采用免疫组化方法检测48例涎腺腺样囊性癌、18例多形性腺瘤和10正常腮腺组织中Twist蛋白的表达情况,分析Twist表达与腺样囊性癌临床病理因素的关系。结果Twist在涎腺腺样囊性癌组织中的表达水平明显高于多形性腺瘤和正常腮腺组织(P<0.05)。Twist表达与腺样囊性癌的病理分型、嗜神经侵袭、术后复发及远位转移有相关性(P<0.05)。结论Twist蛋白表达可能与涎腺腺样囊性癌的分化调节、嗜神经侵袭及远位转移有关。检测Twist的表达水平对判断腺样囊性癌患者的预后有一定的参考价值。
Objective To investigate the expression of Twist in salivary adenoid cystic carcinoma（SACC） and its clinicopathological significance. Methods The expression of Twist was examined immunohistochemically in 48 cases of SACC,18 of pleomorphic adenoma and 10 of normal parotid gland.The relationship between Twist expression and clinicopathological factors was analyzed. Results Twist expression was significantly higher in SACC tissues compared with pleomorphic adenoma and normal parotid gland tissues （P〈0.05）.Twist expression levels in SACC were significantly associated with histological type,perineural invasion,postoperative recurrence and distant metastasis （all comparisons,P〈0.05）. Conclusions Twist expression may be associated with tumor cell differentiation,perineural invasion and metastasis of SACC.Twist expression is a potential prognostic factor for disease survival of SACC.
出处
《实用肿瘤杂志》
CAS
北大核心
2009年第5期441-445,共5页
Journal of Practical Oncology
关键词
涎腺肿瘤
肿瘤侵润
肿瘤转移
蛋白Twist
预后
salivary gland neoplasms
neoplasm invasiveness
neoplasm metastasis
Twist protein
prognosis
