摘要
目的:分析头颈部恶性纤维组织细胞瘤(MFH)的临床特征和治疗方法。方法:回顾性分析28例头颈部MFH患者的临床资料,其中上颌骨9例,鼻腔3例,喉部5例,腮腺3例,颞骨3例,甲状腺1例,头颈软组织4例,均经免疫组织化学检测确诊。单纯手术切除4例,手术加放疗23例,单纯放疗1例。结果:5例1年后失访,按死亡计算,余均随访3年以上,1、3年生存率分别为96.4%(27/28)和57.1%(16/28);随访满5年23例,5年生存率为26.1%(6/23)。3年内复发率为60.7%(17/28),复发次数1～7次,平均复发时间为5.6个月,复发者1例采用放疗,12例采用非定型手术扩大切除。结论:头颈部MFH的确诊有赖于免疫组织化学技术,早期诊断、广泛手术切除、综合治疗能减少复发,提高生存率;复发者可采用非定型手术扩大切除以延长生命。
Objective： To analyze the clinical feature and treatment of head-neck malignant fibrous histiocytoma （MFH）. Method：A retrospective analysis on the clinical data of 28 cases of MFH were carried out, of which 9 were in the maxilla, 3 in the nasal cavity, 5 in the larynx, 3 in the parotid, 3 in the temporal bone, 1 in the hypothyroid, and 4 in the head and neck region. All of the cases underwent immune histochemistry： 4 cases of surgery alone, 23 cases of surgery followed by radiotherapy, and 1 case of radiotherapy alone. Result： Except 5 cases lost follow-up after 1 year, all the other cases were followed-up over 3 years, the survival rate for 1 or 3 years was respectively 96.4% （27/28） and 57. 1% （16/28）; 23 cases were followed up for 5 years, the survival rate was 26.1%（6/23）. The recurrent rate in 3 years was 60.7%（17/28） ,with 1 to 7 times recurrence at a mean interval of 5.6 months. Twelve recurrent cases were adopted expanded resection of non-defined operation except 1 case with radiotherapy. Conclusion：The diagnosis of MFH depends on the technology of immune histochemistry. Early diagnosis, expanded resection, and integrated therapy could reduce the recurrence and increase the survival rate; the recurrence could adopt expanded resection of non-defined operation to prolong the life.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2009年第19期886-888,893,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
