摘要
为了解重型乙型肝炎时乙型肝炎病毒（ＨＢＶ）的复制状况，应用酶联免疫吸附实验和聚合酶链反应测定了５６例乙型肝炎病人的ＨＢＶ复制指标。慢性重型肝炎病人的ＨＢｅＡｇ和／或ＨＢＶ－ＤＮＡＰＣＲ阳性率明显低于非重型慢性肝炎（Ｐ＜０．０１），表明ＨＢＶ复制活跃不一定是重型肝炎发生的因素之一。
In order to elucidate the relationship between hepatitis B virus (HBV) replication and severity of hepatitis B, HBV serological markers and HBVDNA in 56 patients with chronic hepatitis B were detected using the methods of ELISA and PCR, respectively. The results showed that the positive prevalence of HBeAg and/or HBVDNA in chronic severe hepatitis B (5/25) was much lower than that in nonsevere chronic hepatitis B (26/31) (P<0.01). The study provides the suggestive evidence that viral replication is significantly reduced in severe hepatitis B. Also, increased replication of HBV appears to be not the cause of hepatic necrosis in severe hepatitis B.
出处
《湖南医科大学学报》
CSCD
1998年第4期391-392,共2页
Bulletin of Hunan Medical University
