摘要
目的 评价新型混合生物人工肝支持系统治疗重型病毒性肝炎肝功能衰竭的临床疗效。方法 联合应用血浆置换装置、血浆灌注活性炭吸附器和内含 1× 10 9个聚集培养人或猪肝细胞的生物反应器 ,共同构成混合型生物人工肝支持系统 ,对 10例重型病毒性肝炎患者进行人工肝支持与治疗。结果 10例混合生物人工肝支持患者中 ,7例有显著疗效。主要表现为治疗后精神、中毒症状明显好转 ,血清总胆红素显著下降 ,凝血酶原时间缩短。 2例肝昏迷 (Ⅲ度肝性脑病 )患者治疗中或治疗后清醒 ,4例Ⅱ度肝性脑病消失。最终有 3例好转出院 ,2例成功等到肝移值 ,5例因肝功能衰竭本身并发症和病情反复而死亡或自动出院。结论 混合生物人工肝支持系统对重型病毒性肝炎肝功能衰竭有明显的支持治疗作用。
Objective To evaluate the efficacy of a new hybrid bioartificial liver support system in the treatment of severe viral hepatitis. Methods A hybrid liver support system consisting of plasma exchange device, plasma perfusion column (charcoal) and a hollow fiber reactor inoculated with 1×10 9 aggregated human hepatocytes or porcine hepatocytes was developed. Ten patients with severe viral hepatitis were treated using this hybrid system. Results The effective rate of the hybrid bioartificial liver support system was 70% (7/10). The mental status and signs of toxicity of patients were improved markedly. Two patients of coma Ⅲ woke up and grade Ⅱ encephalopathy in 4 patients disappeared after treatment. At the same time, a marked decrease in total serum bilirubin and prothrombin time was noted after treatment. Finally, Three out of 10 patients recovered completely. Two patients were bridged to liver transplantation. Five patients died from the complication of hepatic failure or discharge refused advice due to worsening of disease.Conclusions The evident clinical improvement shows that this artifical liver system has prominant liver support effects for the patients with severe viral hepatitis and liver failure.
出处
《中华传染病杂志》
CAS
CSCD
北大核心
2002年第1期14-16,共3页
Chinese Journal of Infectious Diseases
基金
国家"九五"攻关项目 ( 96 92 0 12 0 2 )
高等学校全国优秀博士学位论文作者专项基金资助项目 (199947)
关键词
生物人工肝
肝支持
重型肝炎
肝衰竭
Bioartificial liver
Liver support
Severe hepatitis
Hepatic failure
