摘要
目的了解我院药品不良反应(ADR)发生的临床特点,促进临床合理用药。方法采用描述性研究方法对2008年我院407例ADR报告进行统计分析。结果407例ADR中,女性多于男性,男女之比为0.84∶1;>50岁的中、老年患者166例,占40.79%;单一用药384例,联合用药23例,静脉给药为发生ADR的主要给药途径。抗感染药物是引起ADR的最常见药物占36.4%,其次为中药制剂占11.8%;皮肤及附件是最常见的ADR损害部位,占49.4%;根据ADR程度分类,中度363例,重度只有2例。对ADR因果关系进行评定,具有肯定因果关系27例,很可能258例,可能106例,可疑16例;治愈227例,好转180例。结论应加强ADR的监测和ADR知识的宣传,避免或减少其重复发生。
Objective Understood the adverse drug reactions （ADR） occurrence of the clinical features in our hospital, and improved the level of clinical use of drugs. Methods 407 ADR reports occurred in 2008 were analyzed by a descriptive research method. Results Among the 407 cases,female cases out numbered the male cases with the ratio at M：F = 0.84：1;166 cases were the elderly at the age of more than 50 which accounts for 40.4% of the total;there were 384 single medication cases and 23 combined medication cases, intravenous administration was the main route of administration. Anti-infectives drug was the most common caused ADR accounted for 36.4% ; then chinese traditional medicines at a percentage of 11.79% ;skin and its appendages impairment cases were the most with a percentage at 49.39% ;According the degree of ADR classification, there were 2 severe cases,363 moderate cases. To evaluate the causal relationship between ADR, there were 27 certain cases, 106 probable cases and 16 possible cases;227 patients were fully recovered, 180 cases showed some improvement. Conclusion Monitoring and publicizing of ADR knowledge should be emphasized, so as to lessen or avoid the occurrence of ADR.
出处
《临床合理用药杂志》
2009年第19期45-47,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
药品不良反应
监测
统计
报告
分析
Adverse drug reaction
Monitoring
Statistics
Reports
Analysis
