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脑钠肽在充血性心力衰竭中的价值分析 被引量：6

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摘要 目的:观察充血性心力衰竭(CHF)患者脑钠肽(BNP)水平的变化,以及在CHF中的诊断价值及其灵敏度和特异度。方法:心力衰竭组共80例,平均年龄(64±15)岁。根据NYHA心功能分级标准将心力衰竭组又分为心功能Ⅱ级组2 4例、Ⅲ级组2 6例、Ⅳ级组3 0例。又按射血分数(EF)将心力衰竭组分为EF<4 0%组4 2例和≥4 0%组38例。对照组50例,为非心力衰竭患者,平均年龄(63±6)岁。用放射免疫法测定BNP的浓度,用心脏彩色多普勒超声心动图测定左室射血分数(LVEF)和左室舒张末内径(LVED)。结果:心力衰竭组总体BNP水平较非心力衰竭组显著升高(P<0.05)。BNP在NYHA心功能Ⅲ级组较Ⅱ级组显著升高(P<0.05);仅BNP水平Ⅳ级组较Ⅱ级组显著升高(P<0.05)。BNP水平EF<40%组高于≥40%组(P<0.05)。结论:BNP有助于不同心功能级别的辅助诊断。
作者 赵红卫 刘芳 崔红燕 丁明辉
机构地区 山西医科大学第二医院
出处 《临床医药实践》 2009年第9期655-657,共3页 Proceeding of Clinical Medicine
关键词 脑钠肽 心力衰竭 分析
分类号 R541.61 [医药卫生—心血管疾病]
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参考文献9

  • 1New R B,Sampson A C,King M K,et al. Effects of combined angiotensin Ⅱ and endothelin receptor blockade with developing heart failure :effects on left ventricular performance [J]. Circulation, 2000, 102 (12):1 447-1 453.
  • 2Maeda K,Tsutamota T,Wada A,et al. Plasma brain natriuretic peptide as a biochemical maker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction [J]. Am Heart J,1998,135:825-832.
  • 3Fedak P W,Svetlana M,Altamentova S M,et al. Matrix remodeling in experimental and human heart failure :a possible regulatory role for TIMP-3[J]. Am J Physiol Heart Cire Physiol,2003,284:626-634.
  • 4Field S J. E2F-1 functions in mice to promote apopote apoptosis and suppress proliferation[J]. Cell,1996,85:86.
  • 5Maisel A S, Krishnaswamy P, Nowak R N,et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure[J]. N Engl J Med,2002,347(3):161-167.
  • 6Suzuki T, Yamaoki K, Nakajima O, et al. Screening for cardiac dysfunction in asymptomatic patients by measuring B-type natriuretic peptide levels[J]. Jpn Heart J,2000,41:205.
  • 7李静宇,王宇航,杨志新.放免法测定血浆脑钠素水平诊断无症状性心力衰竭[J].中国卫生检验杂志,2000,10(4):454-455. 被引量：18
  • 8解丽艳,王晏平,范茜,刘萍,董海.老年人心力衰竭与C-反应蛋白肾上腺髓质素脑钠素和基质金属蛋白酶的关系[J].中华老年医学杂志,2005,24(9):655-658. 被引量：9
  • 9Beinhardt D,Sigusch H H,Hen B E,et al. Cardiac remodeling in end stage heart failure:upregulation of matrix metalloproteinase irrespective of the underlying disease,and evidence for a direct inhibitory effect of ACE inhibitors on MMP[J]. Heart, 2002,88:525-530.

二级参考文献19

  • 1雷秉钧.临床科研设计、衡量与评价 第三讲 病因及因果关系的研究和评价[J].中国实用内科杂志,1994,14(12):750-752. 被引量：5
  • 2Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med,1999,340:448-454.
  • 3Alonso-Martinez JL,Llorente-Diez B,Echegaray-Agara M, et al. C-reactive protein as a predictor of improvement and readmission in heart failure. Eur J Heart Fail, 2002,49: 331-336.
  • 4Kitamura K, Kangawa K, kawamoto M, et al. Adrenomedullin:a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun, 1993,192: 553-560.
  • 5Bettencourt P, Ferreira A, Dias P, et al. Evaluation of brain natriuretic peptide in the diagnosis of heart failure. Cardiology, 2000,93:19-25.
  • 6Suzuki T,Yamaoki K, Nakajima O, et al. Screening for cardiac dysfunction in asymptomatic patients by measuring B-type natriuretic peptide levels. Jpn Heart J,2000,41:205.
  • 7Field SJ. E2F-1 functions in mice to promote apopote apoptosis and suppress proliferation. Cell, 1996,85: 54.
  • 8Fedak PW, Svetlana M, Altamentova SM, et al. Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3. Am J Physiol Heart Cire Physiol, 2003,284: 626-634.
  • 9Beinhardt D , Sigusch HH, Hen BE, et al. Cardiac remodeling in end stage heart failure: upregulation of matrix metalloproteinase (MMP) irrespective of the underlying disease, and evidence for a direct inhibitory effect of ACE inhibitors on MMP. Heart, 2002, 88:525-530.
  • 10Levine M, Kalman J, Mayer L, et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Eng J Med, 1990,323:236-241.

共引文献24

同被引文献43

引证文献6

二级引证文献33

临床医药实践
2009年 第9期

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