摘要
目的探讨重组人脑利钠肽(recombinant human brain natriuretic peptide,rhBNP)对急性ST段抬高型心肌梗死患者心功能及炎症因子的影响。方法选取急性ST段抬高型心肌梗死患者36例,随机分为实验组(静脉注射rhB-NP组)18例和对照组(静脉注射硝酸甘油组)18例。两组患者均在治疗前、用药后24、48、72 h采用超声心动图检测左室射血分数(LVEF),并在治疗前及治疗7 d后采用酶联免疫(ELISA)方法测定各组患者用药前后血清中C-反应蛋白(C reactive protein,CRP)、肿瘤坏死因子-α(Tumor necrosis factor,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)的含量。结果两组患者治疗后各时点LVEF较治疗前均明显升高(P<0.05)。经治疗7 d后,两组CRP、TNF-α、IL-6的含量水平均较治疗前明显下降(P=0.042、P=0.045、P=0.020)。结论 rhBNP可能通过调节急性ST段抬高心肌梗死患者血清CRP、TNF-α、IL-6水平,改善患者的心功能。
Objective To evaluate the effects of the recombinant human brain natriuretic peptide（rhBNP） cardiac function and inflammatory factors in patients who had heart failure after acute ST elevation myocardial infarction.Methods A total of 36 patients who had heart failure after acute ST elevation myocardial infarction were randomly divided into two groups,treatment group（n = 18） and control group（n = 18）.The treatment group was treated with rhBNP.The control group was treated with Nitroglycerin.In each group,left ventricle ejection fraction（LVEF） was measured by echocardiography on the day before the treatment,24 hours,48 hours and 72 hours after treatment respectively.In addition,the levels of CRP,TNF-α and IL-6 were measured by enzyme-linked immunosorbent assay（ELISA） on the day before treatment and the 7th day after treatment.Results The LVEF at each time point obviously increased more than before treatment in all of the two groups（P 0.05）.And the levels of CRP,TNF-α and IL-6 before treatment in both groups respectively had more significant reduce than that after treatment in the 7th day（P = 0.042,P = 0.045,P = 0.020）.Conclusion Through adjusting the levels of serum CRP,TNF-α and IL-6,rhBNP can improve the cardiac function of the patients with heart failure after acute ST elevation myocardial infarction.
出处
《中国医药导报》
CAS
2012年第30期54-55,58,共3页
China Medical Herald
关键词
重组脑利钠肽
心肌梗死
心功能
炎症因子
rhBNP
Myocardial infarction
Cardiac function
Inflammatory factor
