摘要
目的:检测自然流产、不孕患者的抗心磷脂抗体(ACA)水平,探讨它们之间的关系及临床意义。方法:采用酶联免疫吸附法(ELISA法)检测85例自然流产患者(流产组)、32例不孕患者(不孕组)与42例健康者(对照组)血清中ACA-IgG、ACA-IgM及ACA-IgA3种抗体,并进行比较。结果:不孕组ACA总阳性率为40.6%,流产组为38.8%,均显著高于对照组(4.7%)(P<0.01)。其中,1次流产者ACA阳性率为20.0%;2次流产者ACA阳性率为45.6%;习惯性流产者ACA阳性率为68.2%,有显著性差异(P<0.05);且晚期流产患者ACA阳性率为44.4%,早期流产患者ACA阳性率为17.3%,两者比较,有非常显著性差异(P<0.01)。结论:ACA是导致自然流产与不孕的免疫学因素之一,与习惯性流产和晚期流产关系密切。
Objective： To detect the level of anticardiolipin antibody （ACA） in patients with infertilhy and abortion, and explore the relationships between anticardiolipin antibody and abortion as well as infertility. Methods： Serum ACA, including IgG, IgM and IgA, was detected by ELISA in 32 cases of infertility （infertility group）, 85 cases of abortion （abortion group） and 42 normal women （control group）. Results： The total positive rates of ACA in infertility and abortion group were 40.6% and 38.8% respectively, these were significantly higher than that of control group （4.7%） （P〈0.01）. Among the patients with once, twice or habitual abortion, the positive rates of ACA were 20.0%, 45.6% and 68.2% respectively. There was significant difference among the three groups （P〈0.05）. Furthermore, the positive rates of ACA in late and early abortion patients were 44.4% and 17.3% respectively, there was also obvious difference between the two groups （P〈0.01）. Conclusion： ACA is one of the immunological factors in the process of infertility and abortion, and ACA closely connects with habitual abortion and late abortion.
出处
《中国医药导报》
CAS
2009年第27期28-29,共2页
China Medical Herald
关键词
抗心磷脂抗体
自然流产
不孕
酶联免疫吸附法
Anticardiolipin antibody
Abortion
Infertillty
Enzyme-linked immumosorbent assay
