摘要
在动物实验的基础上，比较了抗ＡＦＰ单克隆抗体（ｍＡｂ）和抗ＡＦＰ多克隆抗体（ｐＡｂ）两种不同抗体双弹头标记物在肝癌患者体内的生物代谢情况。结果显示，两种抗体标记物的血浆清除半衰期均在２４ｈ左右，ｍＡｂ标记物的清除较ｐＡｂ标记物略慢。尿清除的半衰期，ｍＡｂ标记物约为１２０ｈ，而ｐＡｂ标记物则约为１８ｈ，表明二者的体内生物代谢不同，疗效可能不一。
Based on the experimental animals, the in vivo metabolisms of two immunoconjugates, 131 I anti AFP pAb MMC and 131 I anti AFP mAb MMC, which have dual warheads for radioimmunotherapy in patients with primary liver cancer were compared. The results showed that the clearance half lives in plasma were all about 24 hours, with a little longer for 131 I anti AFP mAb MMC. And the half life of excretion of 131 I anti AFP mAb MMC in urine was about 120 h, much longer than that 18 h of 131 I anti AFP pAb MMC. These results suggest that the metabolic mechanisms of the two kinds of labeled agents were different.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
1998年第1期47-50,共4页
Chinese Journal of Cellular and Molecular Immunology
基金
国家八五科技攻关资助
关键词
肝肿瘤
放射免疫治疗
免疫轭合物
生物代谢
liver neoplasm radioimmunotherapy immunoconjugate biological metabolism
