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体外循环心脏手术缺血/再灌注对患者外周血一氧化氮水平的影响 被引量：2

Effect of Ischemia/Reperfusion in Cardiac Surgery withCardiopulmonary Bypss on Nitric Oxide Levelsof Peripheral Blood in Patients
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摘要 为了解体外循环（ＣＰＢ）心脏手术缺血／再灌注对患者外周血一氧化氮（ＮＯ）水平的影响，采用高效液相色谱法测定了２０例患者ＣＰＢ前后多时间点外周血亚硝酸盐（ＮＯ２－）和硝酸盐（ＮＯ３－）浓度，以间接反映血中ＮＯ水平。结果显示：ＣＰＢ心脏手术后患者外周血ＮＯ水平（ＮＯ２－＋ＮＯ３－）呈下降趋势，而且这种下降趋势与ＣＰＢ前后的时间变化存在直线回归关系。作者认为ＣＰＢ后患者外周血ＮＯ释放的下降趋势可能与ＣＰＢ期间缺血／再灌注所致内皮细胞激活有关。 To examine the effect of ischemia/reperfusion in cardiac surgery with cardiopulmonary bypass (CPB) on nitric oxide (NO) levels of peripheral blood, venous levels of NO2- and NO3- were measured at multiple timepoints before, during, and after CPB by means of highpressure liquid chromatograph to reflect NO concentration indirectly in 20 patients. The results showed there was a linear regresion between the decreased trend of NO release and the change of time at the period of periCPB. We believe that the decreased trend of NO release at the period of periCPB is related to the endothelial cell activation caused by ischemia/reperfusion at the same time. Therefore it is necessary to explore the regulation and action of NO release during systemic inflammatory response procedure in CPB.
作者 肖锡俊 梁茂植 余勤 黄英 周蓬 张祥蓉 曾维渝 田子朴
出处 《华西医科大学学报》 CSCD 1998年第3期302-306,共5页 Journal of West China University of Medical Sciences
基金 四川省卫生厅科学基金
关键词 体外循环 一氧化氮 心脏外科手术 再灌注损伤 Cardiopulmonary bypass Ischemia/reperfusion Nitric oxide
分类号 R654.2 [医药卫生—外科学] R654.1 [医药卫生—外科学]
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参考文献1

  • 1Sato H，J Thorac Cardiovasc Surg，1995年，110卷，2期，302页

同被引文献31

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引证文献2

华西医科大学学报
1998年 第3期

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