摘要
目的观察食管癌及癌旁组织中P16和CDK4(细胞周期素依赖激酶4)的表达,探讨其对食管癌发病机制。方法潍坊市人民医院病理室的术后食管癌和相应的癌旁组织标本100例(癌旁组织经病理证实不存在癌细胞)。HE染色后由病理学医师对组织学类型进行病理诊断。采用S-P免疫组织化学染色方法检测食管癌和癌旁组织中P16和CDK4的表达。结果食管癌和癌旁组织中P16阳性率分别为37%、78%,两组间比较存在显著性差异(P<0.01)。食管癌和癌旁组织中CDK4阳性率分别为72%、34%,两组间比较存在显著性差异(P<0.01)。结论CDK4可考虑用作食管癌的肿瘤标志物。
Objective To observe the expression of P16 and CDK4 in esophageal carcinoma and precancerous tissue and discover the esophageal carcinoma nosogenesis. Methods A total of 100 patients who had undergone surgical resections of esophageal carcinoma in our hospital were selected for our study. We examined sections from esophageal carcinoma and precancerous tissue. HE staining was performed for pathological diagnosis. The expression of P16 and CDK4 was determined by SP immunohistochemical method. Results The positive rate of P16 expression in esophageal carcinoma and precancerous tissue were 37% and 78%, with a significant difference between two groups（P 〈 0.01 ）. The positive rate of CDK4 expression in esophageal carcinoma and precancerous tissue are 72% and 34%,with a significant difference between two groups（P〈 0.01 ）. Conclusion CDK4 can be considered as a cancerous marker of esophageal carcinoma.
出处
《中国现代医生》
2009年第25期17-18,共2页
China Modern Doctor
