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癫痫与氧自由基 被引量:7

The epilepsy and oxygen free radical
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摘要 癫痫的发病机制迄今尚未完全阐明,多种因素都能诱导神经元异常放电,触发癫痫。近年来用分子生物学及遗传学方法阐明的癫痫发作机理主要包括:①神经递质及其受体调控异常;②离子通道改变;③细胞程序性凋亡;④自由基的产生等。自由基能引起氧化应激损伤,最终导致癫痫的发生。清除氧自由基、抗氧化的治疗方法能为癫痫的药物治疗提供新的靶点。
作者 谢彦 孙红斌
出处 《实用医院临床杂志》 2009年第3期126-129,共4页 Practical Journal of Clinical Medicine
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