摘要
目的以人胃癌细胞株裸鼠腹腔种植模型，比较术后早期和延期腹腔内化疗对胃癌细胞腹腔种植生长的影响程度。方法３４只雄性裸鼠腹腔内接种ＭＫＮ┐４５细胞（３×１０６细胞数／只）后，随机分成对照组和４个不同剂量、不同时间表阿霉素腹腔内化疗组。结果对照组裸鼠致瘤率为６／６（１００％），０．４ｍｇ·ｋｇ－１·ｄ－１和０．８ｍｇ·ｋｇ－１·ｄ－１表阿霉素早期腹腔内化疗（接种后１～３天）的致瘤率分别为２／７和１／７；前两种不同剂量表阿霉素的延期腹腔内化疗（接种后５～７天）的致瘤率均为６／７。早期腹腔内化疗的抑瘤作用明显高于延期腹腔内化疗（Ｐ＜０．０５）。结论在预防胃癌术后腹腔内种植复发时，术后早期腹腔内化疗优于术后延期腹腔内化疗。
Objective:A comparison between early postoperative intraperitoneal chemotherapy(EPIC) and delayed postoperative intraperitoneal chemotherapy(DPIC) was carried out in nude mice implanted with human gastric cancer cells intraperitoneally.Methods:Thirtyfour athymic BALB/c(nu/nu) nude mice (male,4～6 weeks old) were inoculated with gastric cancer cell(MKN45) suspensions (3×106 of cells per mouse ) intraperitoneally. These mice were divided randomly into a control group and four treated groups that received epirubicin of different doses and at different time intervals.Results:Tumor formation occurred in 6/6 mice of the control group; and 2/ and 1/7 in the groups respectively injected with 0.4 and 0.8 mg·kg-1·d-1 of epirubicin dissolved in 40 ml·kg-1 of Ringer′s lactate (RL) solution for first 1～3 days(EPIC) after inoculation; and 6/7, 6/7 in the groups which received the same doses of epirubicin during days 5～7(DIPC) respectively. Thus, a significant difference exists between EPIC and DPIC(P<005).Conclusion:The study indicates that EPIC is more effective than DPIC in preventing postoperative intraperitoneal recurrence of tumor.
出处
《肿瘤》
CAS
CSCD
北大核心
1998年第4期264-266,共3页
Tumor
关键词
腹腔内
胃癌
腹腔种植
药物疗法
Intraperitoneal chemotherapy Gastric cancer Peritoneal implantation
