摘要
通过对Wistar大鼠颈内动脉注入血凝块栓子．制作多发性脑梗塞模型，模拟人类多发性梗塞痴呆的病理损害，研究不同脑区AVP含量的变化。结果表明模型组与对照组相比，在水迷宫中游全程的时间显著延长，正确次数明显减少（P＜0．01）。采用放射免疫测定法测定额叶、顶叶、海马、纹状体四个脑区内AVP含量，模型组比对照组含量显著降低（54％～73％，P＜0．01）。实验结果揭示：这种多发生梗塞模型是成功的，大鼠的学习、记忆障碍可能与重要脑区使塞后AVP含量下降有关。
The Chen's rncthod was uscd to prcparc the midel of thc MID rats,and the water maze test was used to verify the changcs of lcarning and mcmory functions. Radioimmunoassay was carried out to observe the changes of somatostatin(AVP) in 4 brain regions of MID rats and the controls. The concentrations of AVP were reduccd (by 54%~ 73%) significantly in the frontal,parietal lobe,striatum and thalamus of the MID rats as compared with the controls. Thc results indicate that the defieits in learning and memory function rnight be related to the dccreascs of AVP aftcr multiple infarctions.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1998年第4期236-237,共2页
Chinese Journal of Gerontology
基金
吉林省卫生厅科研基金
关键词
精氨酸加压素
痴呆
放射免疫法
脑梗塞
Arginine vasopressin
Multi-infarct dementia
Radiommunoassay
