摘要
应用RIA方法．检测627例血清睾酮（T）、促黄体生成素（LH）和泌乳素（PRL）水平．探讨各激素的增龄性变比。结果表明：血清T水平对照组为32．07±14．25nmol／L其它各组随增龄呈进行性降低．且与对照组相比存在显著差异（P＜005）：血清LH水平是随龄增高趋势．且与T变比呈显著负相关（r=－0．21，P＜0．01）。血清PRL水平亦呈现随龄增高趋势。PRL与T（r=－0．12．P＜0.05）、PRL与LH（r=0．11．P＜0．05）呈微弱相关关系。上述结果提示．在男性衰老过程中．T水平逐渐降低．对LH负反馈抑制作用减弱，而引致LH分泌增高．血清PRL对性腺轴激素水平有影响．但其具体作用及作用方式有待进一步研究。
Age-related changes of serum LH,PRL and testosterone were measured in 627 healthy elderly. Serum testosterone levels declined significantly with age(r = - 0. 386,P＜0.005) while LH levels increased,and changes of serum testosterone levels were correlated with LH levels(r = - 0. 21,P＜0.01). PRL was also increased with age,and slightly correlated with either serum testosterone or LH(r = - 0. 12,P＜0. 05 and r = - 0. 11,P＜0. 05 respectively). It is concluded that the decrease of testosterone Production after aging attenuated the sensitivity of testosterone feedback and resulted in elevation of LH production. PRL may modify testosterone feedback,but the pathway and process rernained to be elucidated.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1998年第4期195-197,共3页
Chinese Journal of Gerontology
基金
卫生部科研基金!96-2-180
