摘要
探讨哮喘患儿急性发作期与缓解期单个核细胞（PBMC）产生IL－、IFN－γ水平与IgE的关系。方法用ELISA方法测血清IL-4、IFN-γ和IgG水平，对检测结果统计学处理。结果哮喘急性期和缓解期血清IL-4水平分别为260．1±29．1ng／L和193．7±44．0ng／L（P＜0．001），IFN－γ分别为462．4±69．1ng／L和548．1±78．0ng／L（P＜0．001），Ige分别为2649．36±1413．88U／L和1726．39±1100．22U／L（P＜0．001），IL－4与IgE水平呈明显正相关。结论哮喘患儿急性发作期血清IL－4、IgE水平明显高于缓解期，IFN－γ低于缓解期，IL－4、IFN－γ和IgE在哮喘发病中具有重要作用。
Objective To observe the relationship betweew serum IgE andthe levels of IL-4 and IFN-γproduced by PBMC in acute andrestoration stage of asthma.Methods The serum IL-4, IFN-γ and IgE were determined byELISA. The statistical treatment of the results was carried out.Results In acute and restoration stage of asthma, the patients'serum levels of IL-4 were 260. 1± 29. 1 ng/L and 193. 7±44. 0 ng/Lrespectively (P＜0. 001 ), IFN-γ were 462. 4±69. 1 ng/L and 548. 1±78. 0 ng/L respectively (P＜ 0. 001 ), and IgE were 2649. 36±1413. 88 U/L and 1726. 39±1100. 22 U/L (P＜0. 001 ). The levelsof IL-4 and IgE showed positive correlation.Conclusions Serum IL-4 and IgE in child patients with asthmain acute stage are higher than that in restoration stage, but theserum IFN-γ is lower. The IL-4, IFN-γ and IgE may play a veryimportant role in asthma.
出处
《实用儿科临床杂志》
CAS
CSCD
1998年第4期193-194,共2页
Journal of Applied Clinical Pediatrics
