摘要
自从抗菌药物在医学、兽医临诊实践中被广泛应用以来,已取得良好的疗效。但抗菌药既能发挥防治疾病的有利作用,也会对动物产生损害作用。盲目、滥用抗菌药物带来的危害值得人们关注和反思。抗菌药物的不良反应和滥用抗菌药物的危害,主要表现为细菌产生耐药性、动物体内菌群平衡失调等,其次是药物残留对公共卫生和环境的负面影响。论文强调在了解药动学和药效学原理(峰时间、峰浓度、药时曲线下面积、防突变浓度、抗菌后效应、最小抑菌浓度等)的基础上,指出应该坚持病因学诊断,制定科学的治疗方案,同时要遵守国家相关的法规和条例,做到依法防控疾病。
The antibacterial drugs have acquired fine curative effects in medical and veterinary practice since these drugs are applied extensively. The drugs have both advantages and disadvantages. People pay close attention to the harm as a result of abuse of antibacterial drugs. In this article, the adverse reaction of antibacterial drugs and relevant harm drug resistance produced by bacteria and imbalance of normal bacterial flora related to drugs were reviewed. The harmful effects of drug residues to public sanitation and environment were presented. The importance for understanding pharmakinectics（PK） and pharmacodynamics（PD）theories （T C AUC, mutant prevention concentration, postantibiotic effect,and MIC, etc） was emphasized. On the basis of PK,PD and etiological diagnoses, the scientific treatment regimen may work out. At the same time, accomplishing the disease prevention and control should be in accordance with the law.
出处
《动物医学进展》
CSCD
北大核心
2009年第8期97-100,共4页
Progress In Veterinary Medicine
关键词
抗菌药物
不良反应
滥用
antibacterial drug
adverse reaction
abuse
