摘要
目的探讨西维来司钠对大鼠脑出血的保护作用。方法将Wistar大鼠随机分为5个组:假手术(sham)组;ICH+生理盐水组(model);ICH+Sivelestat(200mg/kg)组;ICH+Sivelestat(80mg/kg)组;ICH+Sive-lestat(30mg/kg)组,分别于造模后24h进行神经功能缺损评分、脑含水量(BWC)测定和组织病理学观察。结果model组的神经病学评分最高,而各治疗组神经病学评分均底于model组,其中高剂量和中剂量与model组相比差异有显著性意义(P<0.01或P<0.05);大鼠脑出血24h后其脑组织含水量明显升高,与sham组相比具有显著性意义(P<0.01),治疗组(大剂量和中剂量)大鼠脑组织含水量与模型组相比却有明显降低,差别具有显著性意义(P<0.01);假手术组大鼠脑组织没有明显的炎症细胞浸润,ICH大鼠可见大量炎症细胞浸润,西维来司钠治疗组大鼠脑组织病理改变与模型组相比有明显改善,药物剂量越大,脑组织损伤改善越明显,呈剂量依赖性。结论西维来司钠(80mg/kg和200mg/kg)对胶原酶所致的ICH大鼠模型脑组织有明显的保护作用,能明显改善其神经功能缺损症状,减少炎症细胞浸润,减轻脑水肿及脑组织的病理改变。
Objective To explore the protective effect of Sivelestat sodium on intracerebral hemorrhage in rats. Methods Wistar rats were randomly divided into five groups： sham group, model group, and ICH ＋ Sivelestat groups （30, 80, 200 mg/kg）. Neurological deficit score, brain water content and histop^tthological change were observed at 24h after operation. Results Neurological score was the highest in model group. Compared with model group, neurological score was reduced in each treated group, and there was significant difference between model group and 80,200 mg/kg dose groups（ P 〈 0.01 or P 〈 0.05 ）. Brain water content was sig- nificantly decreased as compared with model group（P 〈 0.01 ）. In addition, Sivelestat sodium could alleviate in- flammatory cell infiltration and pathological change of brain tissue in a dose dependent manner. Conclusion Sivelestat sodium has protective effect on cerebral tissue of ICH rats caused by coUagenase by reducing inflammatory cell infiltration and brain water content.
出处
《咸宁学院学报（医学版）》
2009年第3期187-190,共4页
Journal of Xianning Univarsity(medical Sciences)
关键词
脑出血
西维来司钠
大鼠
Intracerebral hemorrhage
Sivelestat sodium
Rat
