摘要
目的探讨心脏生化标志物与无创性检查对冠脉病变的诊断价值。方法对131例经CAG确诊为ACS患者的心脏生化标志物cTnⅠ、CK-MB与ECG及LVEF进行分析,探讨心脏生化标志物与血管病变的关系。结果心脏生化标志物与LVEF呈负相关(P<0.01),是评价心功能状态和判断心肌梗死面积的敏感指标,可独立作为心脏结构改变和心脏不良性重构的标志物;ACS患者血清心脏生化标志物与冠状动脉病变的范围和程度密切相关,多支病变者高于单支病变者,且与冠状动脉狭窄程度具有相关性(P<0.01);心脏生化标志物检测与ECG具有较好的一致性(P<0.01),心脏生化标志物水平与远期(26±10)个月心脏事件发生有关(P<0.01)。结论心脏生化标志物与无创性检测对ACS临床诊断、危险分层和评估预后具有重要的临床价值。
Objective To investigate the diagnostic value for the coronary artery disease using cardiac biochemical markers and non-invasive diagnosis. Methods To analyze cTn Ⅰ , CK-MB, ECG, LVEF of 131 patients diagnosed as acute corovary syndrome （ACS） by CAG. To study the relationships between cardiac biochemical markers and vascular disease. Results The negative correlation was showed between cardiac biochemical markers and LVEF（P〈0.01）. They can be regarded as sensitive indicators evaluating cardiac function and determining the size of myocardial infarction. It may be independently as the markers of heart structural change and the adverse cardiac remodeling. The serum cardiac biochemical markers of ACS patients were closely related to the scope and extent of coronary artery disease. The level of patients with multivessel lesion was higher than that of the single one,and associated with the extent of coronary artery stenosis（P〈0.01）. The detections of cardiac biochemical markers had good consistencies with ECG（P〈0.01）. The levels of cardiac biochemical markers are statistically significant with the occurrences of the long-term [（26±10）months] cardiac events（P〈0.01）.. Conclusion The cardiac biochemical markers and non-invasive detection have important prognostic value of clinical diagnosis, risk stratification and assessment for ACS.
出处
《重庆医学》
CAS
CSCD
北大核心
2009年第17期2196-2198,共3页
Chongqing medicine
