摘要
目的探讨尿激酶加自体血清引流颅脑手术后颅内血肿的安全性和临床效果。方法将76例颅脑手术后颅内残余血肿或再出血患者随机分为观察组和对照组,每组38例,血肿中均置引流管。观察组用尿激酶加自体血清注入治疗,对照组仅用尿激酶注入治疗。利用CT测量原血肿量,引流后第3、7天残余血肿量以及评测两组患者格拉斯哥昏迷(GCS)评分。结果对照组于引流术后第3、7天的平均血肿清除率分别为63.4%和74.5%,观察组分别为80.6%和95.3%,两组之间比较有统计学差异,P均<0.05;GCS评分改善情况亦有统计学差异,观察组引流效果更好。结论在术中置有引流管且在血肿中央的情况下,用尿激酶加自体血清引流颅脑手术后残余血肿或再出血,比仅用尿激酶注入治疗引流效果更好。
Objective To investigate the safety and efficacy of combined infusion of urokinase and autoserum into intracranial hematomas in patients undergoing craniectomy.Methods Seventy-six patients undergoing craniectomy with intracranial hematomas were randomly divided into observation group and control group,each 38 cases,and drainage tube was inserted into the intracranial hematoma.The patients in observation group were treated with the combined infusion of urokinase and autoserum,and those in control group with the infusion of urokinase alone.The volume of hematomas 3 days before and 7 days after operation was measured by CT scan.GCS in two groups were valued.Results The combined infusion of urokinase and autoserum produced evacuation rate of 80.6%（3 days after infusion）and 95.3%（7 days after infusion）.The infusion of urokinase alone showed removal rate of 63.4%（3 days after infusion）and 74.5%（7 days after infusion）.Conclusion The combined infusion of urokinase and autoserum was safe and more helpful than the infusion of urokinase alone into intracranial hematomas in patients undergoing craniectomy.
出处
《华中医学杂志》
2009年第4期188-189,共2页
Central China Medical Journal
关键词
颅脑手术
颅内血肿
尿激酶
自体血清
Craniectomy
Intracranial hematomas
Urokinase
Autoserum
