摘要
目的探讨不能手术的伴有门静脉癌栓(PVTT)的原发性肝癌(PHC)安全而疗效又相对较好的治疗方法。方法回顾性分析2004年7月至2007年2月收治的,行肝动脉栓塞化疗(TACE)联合三维适形放疗(3-DCRT)及单纯行TACE治疗的PHC合并PVTT患者的临床资料。结果TACE+3-DCRT组在近期疗效(原发肿瘤有效率、癌栓有效率)、甲胎蛋白(AFP)定量变化和远期疗效等方面优于TACE组,差异有显著性意义(P<0.05)。两组患者按计划完成治疗,均无严重并发症,差异无显著性意义(P>0.05)。结论TACE联合3DCRT治疗PHC合并PVTT能提高近期疗效,延长生存期,不增加毒副作用。
Objective To explore the safe and effective treament for inoperable primary hepatic carcinoma （ PHC ） with portal vein tumor thrombus （ PVTT）. Methods To analyze the clinical data of 23 cases of PHC with PVTT from July 2004 to February 2007. Transcatheter arterial chemoembolization （TACE） combined three-dimensional conformal radiotherapy （3- DCRT） or simple TACE were carried out. Results There were significant differences in short term efficacy ,quantitative change in AFP and long term efficacy between two groups （ P 〈 0.05 ）. There were no serious complications in the two groups （ P 〉 0. 05 ）. Conclusion TACE combined with 3-DCRT was more effective than TACE alone for inoperable primary hepatic carcinoma with portal vein tumor thromhus,Furthermore, the combination could extend the survival time,without additional side-effects.
出处
《实用医院临床杂志》
2009年第5期54-56,共3页
Practical Journal of Clinical Medicine
关键词
原发性肝癌
门静脉癌栓
肝动脉
化疗栓塞
三维适形放疗
Primary hepatic carcinoma
Portal vein tumor thrombus
Transcatheter arterial
Chemoembolization
Three-dimensional conformal radiotherapy
