摘要
研究了肿瘤热疗中实施组织温度场预示、优化加热及功率调节一体化的问题。基于新近建立的生物传热热波方程，采用双倒易边界元方法，对在一定加热方式下生物组织内的热量传递规律进行了考察。对传统Ｐｅｎｎｅｓ方程和生物传热热波方程的对比研究发现，在针对真实热疗过程中由于调节加热功率而导致的温度场演化进行模拟时，两类方程的预示结果存在明显差别，这提示了在预测和控制生物体内微小温度时所采用的精细模型应是理论基础更为严密的生物传热热波方程，且在瞬变加热作用下尤为关键。文章还研究了血液灌注率在组织温度场发生改变中的作用及其生理学意义。这些研究为建立实用的肿瘤热疗仪器打下了一定的基础。
The integral problems on temperature prediction, heating optimization and power control in tumor hyperthermia are discussed. Based on the newly established thermal wave model of bioheat transfer (TWMBT) and the dual reciprocity boundary element method, the spatial heat propagation in living tissues under certain heating is investigated. It is found there exists distinctive difference between the results predicted by the traditional Pennes' equation and TWMBT, when used to model the temperature evolution in the practical hyperthermia during the control of heating power. This suggests that the accurate model for predicting and controlling the minimal tumor temperature should be the TWMBT which is founded on the more strict theoretical basis, and the consideration is especially important in the transient heating. The paper has also studied the role and the physiological significance of the blood perfusion in the temperature maintenance. It has provided certain foundations for constructing the practical instrument of tumor hyperthermia.
出处
《清华大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
1998年第7期86-89,101,共5页
Journal of Tsinghua University(Science and Technology)
基金
国家自然科学基金
关键词
加热
肿瘤热疗
组织温度场
温度控制
bioheat transfer
thermal wave
dual reciprocity boundary element method
intervenient heating
tumor hyperthermia
temperature control
