摘要
目的:采用高效液相色谱法(HPLC)测定贝诺酯的有关物质及其含量。方法:色谱柱为C18,流动相为甲醇-水(磷酸调pH3.5)(56:44),紫外检测器,波长240 nm。结果:贝诺酯与对乙酰氨基酚及其他未知杂质均可完全分离,检测了贝诺酯的有关物质,测定了贝诺酯的含量。结论:HPLC法可有效控制贝诺酯的有关物质及其含量。
Objective：To investigate the related substances and to determine the contents of benorilate with a new HPLC method. Methods：A C18 column was used.The mobile phase consisted of methanol and water（56：44,pH adjusted to 3.5 with phosphoric acid）.The UV detector was set at 240 nm.Results：Benorilate, paracetamol and other unkown related substances could be separated.The impurities from benorilate products were tested and the contents of benorilate were determined.Conclusion ：The new method can be used to detect the related substances and determine the contents of benorilate.
出处
《现代医药卫生》
2009年第17期2590-2591,共2页
Journal of Modern Medicine & Health
