摘要
为探讨膀胱移行细胞癌组织中肿瘤微血管不同类型与浸润和转移的关系，应用免疫组织化学ＳＰ法在６１例膀胱移行细胞癌组织中对第Ⅷ因子相关抗原进行表达并计数，根据肿瘤组织中微血管（ＭＶ）的分布特点及其与肿瘤组织的关系，将ＭＶ分为两型：Ⅰ型为肿瘤组织内ＭＶ，位于癌组织内，血管迂曲，扩张，变形；Ⅱ型为肿瘤旁ＭＶ，位于肿瘤边缘，血管分布不均。结果显示浸润性癌组的Ⅱ型ＭＶ数显著高于Ⅰ型ＭＶ数（Ｐ＜００５），在浅表性癌组中Ⅰ，Ⅱ型ＭＶ数之间无显著性差异（Ｐ＞００５），伴淋巴结转移的癌组织Ⅱ型ＭＶ数显著高于Ⅰ型ＭＶ数（Ｐ＜００５）。认为肿瘤血管的生长有很大的异质性，肿瘤边缘的微血管与肿瘤的浸润有密切关系。
To evaluate how microvessels correlated with metastasis and infiltration in transitional cell bladder carcinoma,microvessels were investigated by immunostaining endothelial cells for factor Ⅷ related antigen in 61 cases of transitional cell bladder carcinoma.Two characteristic types of microvessels were observed as their distribution and relationship to the tumor is concerned:the inner type of microvessels,and the edge type of microvessls.It was observed that there was a significantly difference of the edge type microvessel counts between the infiltrative and superficial bladder tumor (P<0.05),and between those with lympha node metastasis and those without metastasis (P<0.05).It was concluded that tumor angiogenesis is heterogeneouc,the edge type of microvessels being correlated positively with the invasiveness of transitional cell bladder carcinoma.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1998年第7期411-413,共3页
Chinese Journal of Urology
关键词
膀胱肿瘤
微血管
分型
Bladder neoplasms Carcinoma Immunochemistry
