摘要
目的:探讨不同剂量缬沙坦在心力衰竭治疗中的临床价值。方法:99例慢性心力衰竭患者随机分为贝那普利组(A组,10mg/d),缬沙坦常规剂量组(B组,80mg/d)和缬沙坦大剂量组(C组,80mg,2次/d),分别测定3组患者治疗前、治疗6个月后血浆血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、脑钠肽(BNP)水平,左室射血分数(LVEF)变化。结果:3组治疗后,血浆AngⅡ、ALD、BNP水平显著下降,LVEF显著增加(P<0.05)。C组治疗后与A、B组治疗后比较,ALD、BNP显著下降(P均<0.05),LVEF显著增加(P均<0.05)。B组与A组治疗后比较,ALD显著降低(P<0.05),其它指标差异无显著性(P均>0.05)。结论:常规剂量缬沙坦能逆转心室重构,改善心功能,效果与贝那普利相似;大剂量缬沙坦能明显逆转心室重构,改善心功能,效果优于贝那普利和常规剂量缬沙坦。
Objective： To explore the clinical value of different dosage of valsartan in treatment of chronic heart failure （CHF）. Methods： Ninety-nine patients with CHF were randomly divided into three groups： benazepril group （group A, 10mg/d）, conventional dose valsartan group （group 13, 80mg/d） and high dose valsartan group （groups C, 80mg/d, 2 times per day）. Levels of angiotensin Ⅱ （AngⅡ）, aldosterone （ALD） and brain natriuretic peptide （BNP） were detected, and the changes of left ventricular ejection fraction （LVEF） were measured before and 6 months after treatment. Results： BNP, ALD, Ang Ⅱ were decreased significantly in 3 groups （P〈0. 05）,while LVEF increased significantly （P〈0. 05） after the treatment. Compared with those of group A and B, BNP and ALD were significantly decreased while LVEF was significantly increased after treatment in group C （P〈0. 05） . ALD in group 13 decreased significantly compared with that of group A （P〈0.05） , while the other indexes were not significantly changed. Conclusions： valsartan, similar to benazepril, reverses ventricular remodeling and improves cardiac function, high dose valsartan reverses ventricular remodelling and improves cardiac function more effectively than benazepril and conventional dose valsartan.
出处
《内科急危重症杂志》
2009年第4期197-199,共3页
Journal of Critical Care In Internal Medicine
关键词
慢性心力衰竭
贝那普利
缬沙坦
左室射血分数
Chronic heart failure Benazepril Valsartan Left ventrieular ejection fraction
