摘要
测定梗阻性黄痤患者血清TNF生物学活性，并分析患者肝功能指标与TNF活性问的可能关系。方法：本研究共选取梗阻性黄症患者30倒（B），分为非感染性梗阻性黄疸组（C）及感染性梗阻性黄疸组（D）2个组，另设立对照组（A）。观察各组血清ALT、AST、TBil及TNF生物学活性变化。结果：各个指标B、C、D组均较A组显著升高（P＜0．01），D组ALT、AST及TNF水平较C组显著升高（P＜0．05）。相关分析表明，在B、C、D组TNF与ALT、AST呈显著正相关关系，而TBil与TNF则无相关关系。结论：梗阻性黄疸患者血清TNF生物学活性升高，而感染可能是其升高的主要原因。TNF生物学活性升高，可能是引起梗阻性黄疸患者肝脏功能恶化的一个重要因素。
Objective: This study was designed to detect the serum TNF biological activity in patients with obstructivejaundice, and to analyze the possible relations between hepatic function indexes and TNF biological activity. Methods : Thirty patients(B) were selected, who were divided into non - infectious obstructive jaundice group(C) and infectious obstructive jaun-dice group (D). Coned group me established. Such indexes as ALT, AST, TBil and TNF were observed. Results: The levelsof ALT, AST, TBil and TNF were increased in B, C and D. The levels of ALT, ase and TNF were significantly higher inproup D than those in group C(P < 0.01). In group B, C and D, there was positive relationship between TNF and ALF, andbetween TNF and AST(P < 0.05). However , no significant relationship was found between TBil and TNF in those groups . Con-clusion: The serum TNF biological activity increases in patients with obstructive jaundice, and infection may be an importantreason for those. The increased TNF biological activity may be an important factor for the worsened hepatic function in Patientswith obstructive jaundice.
出处
《广东医学》
CAS
CSCD
1998年第7期487-488,共2页
Guangdong Medical Journal
