摘要
给豚鼠每日肌注庆大霉素80mg/kg的同时,喂服补肾药物,共20日。采用测定用药前后听觉脑干诱发电位阈值,耳蜗铺片行毛细胞观察计数,耳蜗超微结构电镜观察等方法。结果证实,补肾药物可保护听毛细胞,有效拮抗庆大霉素所致之听阈升高。说明补肾药物可保护耳蜗结构及功能,减轻庆大霉素的耳毒性反应。
By adopting induction - electricity threshold of brain stem, counting of hairy cells in cochlear membrane, and electromicroscopic exam of ultra microscopic sturcture before and after the administration of the drug, it was shown that kidney tonics can protect the hairy cells, effectively resist the increased of hearing threshold caused by gentamycin, demonstrating that such kidney tonics can protect the cochlear structure and function, minimize the oto - toxicity of gentamycin.
出处
《中医杂志》
CSCD
北大核心
1998年第7期430-431,共2页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金(39370853)
关键词
庆大霉素
补肾药物
聋
中医药疗法
deaf ness/chemical induction deafness/ TCM therapy kidney tonics/therapeutic application
