摘要
目的：探索导致鼻咽癌放射性脑病（ＲａｄｉａｔｉｏｎＥｎｃｅｐｈａｌｏｐａｔｈｙ，ＲＥ）的有关因素，以便在鼻咽癌放疗设计时，制定预防措施。方法：收集经ＣＴ或ＭＲ检查诊断的鼻咽癌ＲＥ１２８例，以１∶２的方式，配同期放疗的鼻咽癌病例对照２５６例。对鼻咽癌ＲＥ的多因素分析采用ｌｏｇｉｓｔｉｃ回归分析。可能影响ＲＥ的观察指标（自变量）共２８０个。结果：一程放疗后ＲＥ的有关因素有Ｘ３０（面颈联合野Ｘ轴），Ｘ３２（耳后野剂量），Ｘ３３（耳后野Ｘ轴），Ｘ３８（左侧入射总剂量）。两程放疗后ＲＥ的有关因素有Ｘ４（合并糖尿病或高血压），Ｘ１９（照射次数），其中Ｘ３３及Ｘ１９为有害因素。结论：（１）鼻咽癌ＲＥ病灶偏一则的原因可能与血管腔狭窄的因素有关。（２）随着照射野的扩大，可能影响脑干型ＲＥ的发病率。
?Objcetives:In order to search for the factors affecting NPC(Nasopharyngeal Carcinoma)patients suffering from RE (Radiation Encephalopathy),to Work out radiotherapy designs of NPC and to make suggestions of taking preventive measures.Methods:128 cases of NPC patients suffering from RE diagnosed by CT or MR examination were compared with 256 cases of radiotherapytreated NPC patients by 1∶2 model and at the corresponding period. Factors affecting NPC patients suffering from RE were analysed by logistic regression. Possible affective RE of observation target (independent variable) accounted for 280 items. Results:The relevant RE facors in patients who received the first course of radiotherapy are X30(the X axial of faciocervical combined field),X32 (the X axial of postear field),X38(total dose of left incident direction).The relevant RE factors in patients Who received rerediotherapy are X4(complicated with diabetes or hypertension),X19(radiotherapeutic number of times),among which X33 and X19 are inyarous factors.Conclusions:The results suggest(1) The possible cause of focus of RE inclined to one side is likely to have certain connection with the narrowing blood vessel,and (2) with the expansion of the radiotherapeutic field,the incidence of brainstem type RE of is likely to be increased.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1998年第4期290-292,共3页
Chinese Journal of Cancer
关键词
鼻咽肿瘤
放射疗法
放射性脑病
ligistic回归
asoharyngeal Neoplasm/Radiotherapy Radiation Encephalopathy/radiation effect Logistic regression
