摘要
目的 检测33例经病理检查证实胃肠道恶性肿瘤患者血清NO、LPO、SOD水平。结果与慢性浅表性胃炎组相比，恶性肿瘤患者NO水平显著低下（P＜0．05），LPO水平显著增高（P〈0．01）；其总SOD（T－SOD）水平降低（P＜0．05），主要系Mn－SOD水平明显降低所致（P＜0．01），而Cu，Zn－SOD则降低不明显。NO含量的降低与T－SOD活性的降低呈显著的正相关关系（r＝0．3471，P＜0．05）。结论恶性肿瘤患者抗氧化能力下降，氧化与抗氧化作用失衡，机体受过氧化损伤严重。特别是NO作为巨噬细胞免疫效应分子，其水平的低下，是肿瘤细胞逃避免疫监视而发生发展的重要机制之一。
Serum Nitric Oxide(NO),LPO content and SOD activity in 33 cases＇patients with gas-trointestinal malignant tumor were detected. The results showed that NO contents in gastrointestinalcancer patients decreased significantly(P＜ 0. 05 ). LPO contents increased significantly (P< 0. 01 ); theactivities of total-SOD and Mn-SOD decreased significantly (P＜ 0. 05, P ＜ 0. 01 ), compared with thegroup of chronic superficial gastritis. There was a positive correlation between serum SOD activity andNO content (r＝0. 3471, P＜0. 05 ). It is conclusion that the ability of anti-oxidization was disturbed andthe patients were superoxidized badly.［
出处
《中国肿瘤临床与康复》
1998年第2期27-28,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
食管癌
胃肠癌
一氧化氮
超氧化物歧化酶
esophagus carcinoma, gastrointestinal carcinoma, nitric oxide(NO), superoxide dis-mutase (SOD), lipoperoxide.
