摘要
对胃肠道癌术后２３例腹腔内化疗（腹腔组）与３２例静脉化疗（静脉组）所致的毒性反应比较分析。腹腔组给予ＤＤＰ３０～６０ｍｇ／Ｍ２，５－ＦＵ１～２ｇ／Ｍ２，加入１Ｌ生理盐水，通过药泵滴入腹腔。静脉组给予ＤＤＰ２０～２５ｍｇ／Ｍ２，５－ＦＵ０５～０７５ｇ／Ｍ２，部分病例加用ＭＭＣ２～４ｍｇ／Ｍ２静注。结果显示，腹腔组出现腹胀较静脉组多，而恶心、呕吐，周围静脉炎，肝、肾功能异常，骨髓抑制等较少、较轻。腹痛、耳鸣及听力下降两组差异无显著性意义。说明腹腔内给药化疗毒性反应少且轻，是一安全的给药途径。
A comparison between 23 cases of toxicity caused by intraperitoneal chemotherapy(intraperitoneal group) and 32 cases of toxicity caused by intravenous chemotherapy(intravenous group).DDP 30～60mg/M2,5-FU 1～2g/M2 were given to abdominal cavity group,dripping through medicine pumps into adbominal cavity together with one litre of normal saline.DDP 20～25mg/M2,5-FU 0.5～0.75g/M2 were given to veinalgroup,together with MMC 2～4mg/M2 to some cases.Results showed more adbominal distension but less nausea,vomiting,phlebitis,abnormal functions of liver and kidney intraperitoneal group than introveous group.There was no difference in abdominal pain, tinnitus or drop of hearing between the two groups.It was proved that intraperitoneal chemotherapy is a safe way of us chemotherapy with less and lighter toxicity.
出处
《中国实用外科杂志》
CSCD
北大核心
1998年第8期458-459,共2页
Chinese Journal of Practical Surgery
关键词
胃肠道癌
腹腔内化疗
静脉化疗
毒性反应
gastroenterie cancer
intraveneous chemotherapy intraperitoneal
chemotherapy
toxicity
