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Wingspan支架治疗症状性颅内动脉狭窄的临床研究 被引量:4

Clinical research on treatment of symptomatic intracranial arterial stenosis with Wingspan stent
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摘要 目的探讨Wingspan支架治疗症状性颅内动脉狭窄的安全性、可行性和远期疗效。方法应用Wingspan支架治疗症状性颅内动脉狭窄患者16例,观察其手术成功率、手术前后狭窄率、症状改善及严重不良事件的发生情况。术后6个月行脑血管造影术观察支架内再狭窄发生率。结果患者术前平均狭窄率为(80.6±12.1)%,Wingspan支架置入后平均残余狭窄率为(20.4±10.2)%,手术成功率100%。30天和6个月内同侧脑卒中的发生率分别为6.3%和12.5%。68.8%患者症状改善明显。5例患者行脑血管造影术复查,1例伴有80%再狭窄。结论 Wingspan支架治疗症状性颅内动脉狭窄成功率高,具有较好的安全性和临床疗效。 Objective To investigate the safety, feasibility and long-term efficacy of the Wingspan stent in treatment of symptomatic intracranial arterial stenosis. Methods Treatment with Wingspan stent was attempted in 16 patients. The technical success rate,average stenosis before and after treatment,major complications and clinical outcome were observed. Conventional cerebral angiography was performed at 6 months after stenting. Results The average pretreatment stenosis was(80.6± 12.1)%. After Wingspan stent placement, the average stenosis was(20.4±10.2)%. The technical success rate was 100%. The rate of ipsilateral stroke within 30 days and 6 months was 6. 3% and 12. 5%, respectively. The symptoms were significantly improved in 68. 8% patients. Five patients underwent conventional cerebral angiography reexamination,in-stent stenosis was detected in one patient with 80 % restenosis. Conclusion Symptomatic intracranial artery stenosis can be treated with Wingspan stent with high rate of technical success,acceptable safety and clinic outcome.
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2009年第8期564-566,共3页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金 国家自然科学基金(30870847)
关键词 颅内动脉疾病 支架 脑血管造影术 颈动脉狭窄 intracranial arterial diseases stents cerebral angiography carotid stenosis
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参考文献6

  • 1Kasner SE,Chimowitz MI, Lynn M J, et al. Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis. Circulation, 2006,113 : 555-563.
  • 2Bose A, Hartmann M, Henkes H, et al. A novel, self-expanding, nitinol stent in medically refractory intracranial atherosclerotic stenoses : The wingspan study. Stroke, 2007,38 : 1531- 1537.
  • 3Fiorella D, Levy EI,Turk AS, et al. UJS multicenter experience with the wingspan stent system for the treatment of intraeranial atheromatous disease: Periprocedural results. Stroke, 2007, 38:881-887.
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同被引文献77

  • 1高峰,杜彬,姜卫剑,董可辉,马宁,徐晓彤.Wingspan支架治疗国人症状性颅内动脉狭窄的初步经验[J].中国卒中杂志,2007,2(7):569-573. 被引量:19
  • 2Chimowitz MI,Lynn MJ,Howlett-Smith H,et al.Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis.N Engl J Med,2005,352:1305-1316.
  • 3Lee TH,Choi CH,Park KP,et al.Techniques for intracranial stent navigation in patients with tortuous vessels.Am J Neuroradiol,2005,26:1375-1380.
  • 4Levy EI,Turk AS,Albuquerque FC,et al.Wingspan in-stent restenosis and thrombosis:incidence,clinical presentation,and management.Neurosurgery,2007,61:644-650.
  • 5Schumacher HC,Meyers PM,Higashida RT,et al.Reporting standards for angioplasty and stent-assisted angioplasty for intracranial atherosclerosis.Stroke,2009,40:e348-e365.
  • 6Samuels OB,Joseph GJ,Lynn MJ,et al.A standardized method for measuring intracranial arterial stenosis.Am J Neuroradiol,2000,21:643-646.
  • 7Jiang WJ,Xub XT,Jinc M,et al.Apollo stent for symptomatic atherosclerotic intracranial stenosis:study results.Am J Neuroradiol,2007,28:830-834.
  • 8Bose A,Hartmann M,Henkes H,et al.A novel,self-expanding,nitinol stent in medically refractory intracranial atherosclerotic stenoses:the Wingspan study.Stroke,2007,38:1531-1537.
  • 9Groschel K,Schnaudigel S,Pilgram SM,et al.A systematic review on outcome after stenting for intracranial atheroscierosis.Stroke,2009,40:e340-e347.
  • 10Mocco J,Darkhabani Z,Levy EI.Pharos neurovascular intracranial stent:elective use for a symptomatic stenosis refactory to medical therapy.Cather Cardiovasc Intev,2009,74:642-646.

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