摘要
苯胺经氯乙酰化、缩合、重排三步一锅合成Ｎ－苯基－２，６－二氯苯胺，继而再氯乙酰化、环合、水解开环即得双氯芬酸钠，总收率６４％。
N(2,6Dichlorophenyl) aniline prepared from aniline by chloroacetylation,etherification and rearrangement in onepot procedure was subjected to chloroacetylation,cyclization and hydrolysis to afford diclofenac sodium in 64% overall yield based on aniline.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1998年第8期339-341,共3页
Chinese Journal of Pharmaceuticals
