摘要
目的探讨Ⅰ型胶原吡啶交联终肽（ICTP）与强直性脊柱炎（AS）的临床相关性。方法采用实验流行病学方法，对178例AS患者不同情况下血清ICTP阳性分布对比分析。结果OAS患者HLA—B27阳性率为72．47％（129／178），ICTP阳性率为74．16％（132／178），对HLA—B27与ICTP配对分析，x2=0．31，P〉0．05，差异无统计学意义。②AS患者骶髂关节炎X线不同级别ICTP阳性率分别为O级80％，Ⅰ级73．47％，Ⅱ级91．18％，Ⅲ级65％，Iv级0％，x2=31．86，P〈0．005，差异有统计学显著性意义，说明骶髂关节炎x线不同级别之间ICTP阳性率确有不同，其特点是：O级即有较高ICTP阳性率；除Ⅱ级外，ICTP阳性率显示从高到低的下降趋势；Ⅱ级ICTP阳性率为最高，N级最低。③AS血清ICTP的阳性率初诊患者（84．62％）显著高于复诊患者（63．22％），x2=10．62，P〈0．005，差异有统计学显著性意义。结论ICTP能够较客观地、准确地对AS进行临床评价，主要包括早期诊断、判断病情和评价临床疗效。故ICTP可作为AS临床的实验室重要参考指标。
Objective To probe the clinical relation between TCTP and AS. Methods It was prospectively explored that the serum ICTP in 178 cases of AS patients was tested. Results （1）HLA-B27 and ICTP positive rate 72.47%（129/178） and 74. 16% （132/178）,HLA-B27 and ICTP analyzed was no different,P〉0. 05. （2）The ICTP positive rate in the different grades （0--Ⅳ ） were 80. 00% ,73.47% ,91.18%, 65.00% and 0% respectively. The statistical analysis was very significant among each grade（P〈0. 005）,so the ICTP positive rate was truely different. （3）The ICTP positive rate of the first diagno- sis and treatment patients and the repeated diagnosis and treatment patients was 84.62% and 63. 22% respectively,the statistical analysis was remarkablely different（P〈0. 005） ,the former was significantly higher than the latter in the AS pa- tients. Conclusion The ICTP is able to evaluate objectively and accurately the clinical significance,it mainly includes early diagnosis,judging disease condition and treating effect ,so plays an important role in the AS clinical phase.
出处
《现代检验医学杂志》
CAS
2009年第4期94-96,共3页
Journal of Modern Laboratory Medicine
基金
基金项目：陕西省卫生厅科学研究基金（编号08807）.
